Abnormal vascular reactivity in growth hormone deficiency

The reason why patients with growth hormone (GH) deficiency (GHD) are at increased risk for premature cardiovascular death is still unclear. Although a variety of vascular risk factors have been identified in GHD, little is known regarding vascular reactivity and its contribution to premature arteri...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-01, Vol.103 (4), p.520-524
Main Authors: CAPALDO, Brunella, GUARDASOLE, Vincenzo, PARDO, Francesco, MATARAZZO, Margherita, DI RELLA, Francesca, NUMIS, Fabio, MEROLA, Bartolomeo, LONGOBARDI, Salvatore, SACCA, Luigi
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Adult
Biological and medical sciences
Blood Flow Velocity - drug effects
Blood Pressure - drug effects
Blood Vessels - drug effects
Blood Vessels - physiopathology
Cyclic GMP - blood
Dose-Response Relationship, Drug
Endocrinopathies
Female
Forearm - blood supply
Growth Hormone - deficiency
Growth Hormone - therapeutic use
Hormone Replacement Therapy
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Ischemia - physiopathology
Male
Medical sciences
Nitrites - blood
Nitroprusside - pharmacology
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Vasodilator Agents - pharmacology
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Summary:The reason why patients with growth hormone (GH) deficiency (GHD) are at increased risk for premature cardiovascular death is still unclear. Although a variety of vascular risk factors have been identified in GHD, little is known regarding vascular reactivity and its contribution to premature arteriosclerosis. We assessed vascular function in 7 childhood-onset, GH-deficient nontreated patients (age 22+/-3 years, body mass index [BMI] 25+/-1 kg/m(2)) and 10 healthy subjects (age 24+/-0.4 years, BMI 22+/-1 kg/m(2)) by using strain gauge plethysmography to measure forearm blood flow in response to vasodilatory agents. The increase in forearm blood flow to intrabrachial infusion of the endothelium-dependent vasodilator acetylcholine was significantly lower in GH-deficient nontreated patients than in control subjects (P:
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.103.4.520