Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components

The present paper compares the effects of two monounsaturated oils, extra virgin olive oil (EVOO) and high-oleic acid sunflower oil (HOSO), on serum and LDL peroxides, eicosanoid production and the thrombogenic ratio (thromboxane (TX) B2:6-keto-prostaglandin F1α) in fourteen non-obese post-menopausa...

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Bibliographic Details
Published in:British journal of nutrition 2001-01, Vol.85 (1), p.41-47
Main Authors: Oubiña, Pilar, Sánchez-Muniz, Francisco J., Ródenas, Sofía, Cuesta, Carmen
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cholesterol
Cholesterol - blood
Cross-Over Studies
Diet
Dietary Fats, Unsaturated - pharmacology
Disorders of blood lipids. Hyperlipoproteinemia
Eicosanoids - biosynthesis
Eicosanoids - urine
Female
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - urine
Lipid Peroxidation
Medical sciences
Metabolic diseases
Middle Aged
Oleic Acid - pharmacology
Olive Oil
Peroxidation
Peroxides - blood
Plant Oils - pharmacology
Postmenopause - blood
Prostaglandins F - urine
Sunflower Oil
Thromboxane B2 - blood
Variance analysis
Vitamin E - blood
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Summary:The present paper compares the effects of two monounsaturated oils, extra virgin olive oil (EVOO) and high-oleic acid sunflower oil (HOSO), on serum and LDL peroxides, eicosanoid production and the thrombogenic ratio (thromboxane (TX) B2:6-keto-prostaglandin F1α) in fourteen non-obese post-menopausal women. The subjects, mean age 63 (SD 11) years, were assigned to two consecutive oleic acid-rich 28 d dietary periods. EVOO and HOSO represented 62 % of the total lipid intake and were used as the only culinary fat during the first and second dietary periods respectively. Serum peroxides, plasma α-tocopherol and TXB2 levels in stimulated platelet-rich plasma (PRP-TXB2) were significantly higher (P
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN2000230