Tuberculosis in aged gammadelta T cell gene disrupted mice

In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates t...

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Bibliographic Details
Published in:Experimental gerontology 2001-02, Vol.36 (2), p.245-254
Main Authors: Turner, J, Frank, A A, Brooks, J V, Marietta, P M, Vesosky, B, Orme, I M
Format: Article
Language:English
Subjects:
Aging - genetics
Aging - immunology
Aging - pathology
Animals
Chemokines - biosynthesis
Female
Immunity, Cellular
Inflammation - genetics
Inflammation - immunology
Inflammation - pathology
Lung - immunology
Lung - pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Antigen, T-Cell, gamma-delta - genetics
T-Lymphocyte Subsets - immunology
Tuberculosis, Pulmonary - genetics
Tuberculosis, Pulmonary - immunology
Tuberculosis, Pulmonary - pathology
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Summary:In young mice exposed to aerosol infection with Mycobacterium tuberculosis removal of the gammadelta T cell population by targeted gene disruption does not affect the expression of host resistance, but does influence the integrity of the early granulomatous response. The current study demonstrates that in aged gammadelta T cell gene disrupted mice similar immunopathologic changes ensued in both gene knockout and wild type control mice. Changes in cell surface marker expression, evident in other gene knockout models, was not observed in the aged gammadelta T cell knockout mice. These data imply that gammadelta T cell functions previously observed in young mice become much less important as the animal ages.
ISSN:0531-5565