Prospects for Organ and Tissue Replacement

Damage or loss of a tissue or organ is common, costly, and tragic. Advances in mechanical artificial organs and organ transplantation have improved the treatment of organ failure, and advances in molecular immunology, tissue engineering, and stem cell biology offer the promise of even better therape...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2001-02, Vol.285 (5), p.573-576
Main Authors: Niklason, Laura E, Langer, Robert
Format: Article
Language:English
Subjects:
Animals
Artificial Organs - trends
Biocompatible Materials
Biological and medical sciences
Forecasting
Humans
Immunology
Medical research
Medical sciences
Medical technology
Miscellaneous
Organ Transplantation - trends
Prostheses
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Research - trends
Stem cells
Tissue Transplantation - trends
Transplants & implants
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Summary:Damage or loss of a tissue or organ is common, costly, and tragic. Advances in mechanical artificial organs and organ transplantation have improved the treatment of organ failure, and advances in molecular immunology, tissue engineering, and stem cell biology offer the promise of even better therapeutic modalities for treating organ failure in the future. Enhancement of immune tolerance of transplanted tissues, improved understanding of cellular differentiation and tissue development, and advances in biomaterials may enable the de novo creation of implantable tissue and organs for transplantation. Innovative techniques for prevention and treatment of tissue loss and organ failure should improve the quality and length of life.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.285.5.573