Mitochondrial DNA polymorphisms in bipolar disorder

Background: Previous studies suggested mitochondrial abnormality in bipolar disorder: (1) possible contribution of parent-of-origin effect in transmission of bipolar disorder; (2) abnormal brain phosphorus metabolism detected by phosphorus-31 magnetic resonance spectroscopy; (3) comorbidity of affec...

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Bibliographic Details
Published in:Journal of affective disorders 2001-02, Vol.62 (3), p.151-164
Main Authors: Kato, Tadafumi, Kunugi, Hiroshi, Nanko, Shinichiro, Kato, Nobumasa
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Amino Acid Sequence
Base Sequence
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - genetics
Bipolar disorders
Case-Control Studies
Chi-Square Distribution
DNA, Mitochondrial - genetics
Genetics
Humans
Male
Medical sciences
Middle Aged
Mitochondrial DNA
Molecular Sequence Data
Mood disorders
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single-Stranded Conformational
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk factors
RNA, Transfer - genetics
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Summary:Background: Previous studies suggested mitochondrial abnormality in bipolar disorder: (1) possible contribution of parent-of-origin effect in transmission of bipolar disorder; (2) abnormal brain phosphorus metabolism detected by phosphorus-31 magnetic resonance spectroscopy; (3) comorbidity of affective disorders in patients with mitochondrial encephalopathy; (4) increased levels of the 4977bp deletion of mitochondrial DNA (mtDNA) in the postmortem brains. We investigated mtDNA polymorphisms in association with bipolar disorder. Methods: Twelve PCR fragments including all tRNA genes were examined by the single-strand conformation polymorphism method in 43 bipolar patients. All observed polymorphisms were sequenced. Association of these polymorphisms with bipolar disorder was examined by restriction fragment length polymorphism method in 135 bipolar patients and 187 controls. Results: In total, we found 28 polymorphisms including 14 polymorphisms that have not been reported previously. The A10398G polymorphism was significantly associated with bipolar disorder (10398A genotype: 33.1% in bipolar, 22.2% in the control, P
ISSN:0165-0327
1573-2517
DOI:10.1016/S0165-0327(99)00173-1