B1 cells: similarities and differences with other B cell subsets

Since their discovery, B1 B cells’ origins and developmental pathways have eluded characterization. In the past year, focus on B1 B cells has shifted dramatically from developmental to functional aspects of these cells. Most advances have been made in describing the physiological activities of B1 ce...

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Bibliographic Details
Published in:Current Opinion in Immunology 2001-04, Vol.13 (2), p.195-201
Main Authors: Martin, Flavius, Kearney, John F
Format: Article
Language:English
Subjects:
AB-1 cells
Animals
Antigens, CD - immunology
Antigens, CD - metabolism
B cells
B-Lymphocyte Subsets - cytology
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B1 subsets
CD5 Antigens - immunology
CD5 Antigens - metabolism
Cell Differentiation
Cell Survival
Humans
Immunologic Memory
Lymphocyte Activation
Lymphocyte development
marginal zone
Membrane Glycoproteins
Tetraspanin-29
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Summary:Since their discovery, B1 B cells’ origins and developmental pathways have eluded characterization. In the past year, focus on B1 B cells has shifted dramatically from developmental to functional aspects of these cells. Most advances have been made in describing the physiological activities of B1 cells, including their migration, activation by antigen and role in both autoimmunity and malignancy.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00204-1