Baroreflex Sensitivity Inversely Correlates With Ambulatory Blood Pressure in Healthy Normotensive Humans

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-07, Vol.50 (1), p.41-46
• Main Authors: Hesse, Christiane, Charkoudian, Nisha, Liu, Zhong, Joyner, Michael J, Eisenach, John H
• Format: Article
• Language: English
• Subjects: Adult; Arterial hypertension. Arterial hypotension; Baroreflex - physiology; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - physiology; Blood Pressure Monitoring, Ambulatory; Cardiology. Vascular system; Circadian Rhythm; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Female; Fundamental and applied biological sciences. Psychology; Heart Rate; Hemodynamics. Rheology; Humans; Male; Medical sciences; Reference Values; Vertebrates: cardiovascular system
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.107.090308

Patients with hypertension have a blunted sensitivity of baroreflex control of heart period. In these patients, baroreflex sensitivity is positively related to heart rate variability and inversely related to blood pressure variability. We hypothesized that this relationship would also be evident in healthy normotensive subjects and that individuals with higher baroreflex sensitivity would have lower ambulatory 24-hour blood pressure. Twenty-four–hour ambulatory blood pressure and heart rate were recorded in 50 healthy, normotensive, nonobese individuals (31 women and 19 men). The baroreflex was assessed using sequential bolus administration of sodium nitroprusside and phenylephrine, and baroreflex sensitivity was calculated as the slope of the relation between systolic blood pressure and R–R interval during the resulting blood pressure transients. Baroreflex sensitivity was inversely correlated to 24-hour average mean arterial pressure (R=0.49; P