Buserelin acetate microparticle dispersion effects drug release and plasma E(1) levels

We investigated the effect of different dispersion methods on release behavior and efficacy onset following microparticle administration of buserelin acetate (BA) sustained-release injection. In this in vitro release study, the initial dispersion of BA increased with increased stirring speed (p

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Bibliographic Details
Published in:International journal of pharmaceutics 2007-07, Vol.339 (1-2), p.130-138
Main Authors: Usami, Makiko, Misawa, Kazumasa, Yagi, Naomi, Sekikawa, Hitoshi, Nabeshima, Toshitaka
Format: Article
Language:English
Subjects:
Animals
Buserelin - administration & dosage
Buserelin - analysis
Buserelin - chemistry
Chromatography, High Pressure Liquid
Down-Regulation
Estrone - blood
Female
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Microscopy, Electron, Scanning
Microspheres
Rats
Rats, Sprague-Dawley
Solubility
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Description
Summary:We investigated the effect of different dispersion methods on release behavior and efficacy onset following microparticle administration of buserelin acetate (BA) sustained-release injection. In this in vitro release study, the initial dispersion of BA increased with increased stirring speed (p
ISSN:0378-5173