In-vitro release kinetics of cefadroxil-loaded sodium alginate interpenetrating network beads

This paper reports the development of new interpenetrating polymeric networks of sodium alginate with gelatin or egg albumin cross-linked with a common cross-linking agent, glutaraldehyde, for the in-vitro release of cefadroxil. The beads formed were characterized by Fourier transform infra-red spec...

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Bibliographic Details
Published in:European journal of pharmaceutics and biopharmaceutics 2001-03, Vol.51 (2), p.127-133
Main Authors: Kulkarni, Anandrao R., Soppimath, Kumaresh S., Aminabhavi, Tejraj M., Rudzinski, Walter E.
Format: Article
Language:English
Subjects:
Albumins - chemistry
Alginates - chemistry
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Beads
Biological and medical sciences
Calorimetry, Differential Scanning
Cefadroxil
Cefadroxil - metabolism
Cefadroxil - pharmacokinetics
Cephalosporins - metabolism
Cephalosporins - pharmacokinetics
Diffusion
Drug Carriers - chemistry
Fixatives - chemistry
Gelatin - chemistry
General pharmacology
Glucuronic Acid
Glutaral - chemistry
Hexuronic Acids
Hydrogels - chemistry
Interpenetrating network
Medical sciences
Microscopy, Electron, Scanning
Microspheres
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polymers - chemistry
Sodium alginate
Spectroscopy, Fourier Transform Infrared
Water - chemistry
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Summary:This paper reports the development of new interpenetrating polymeric networks of sodium alginate with gelatin or egg albumin cross-linked with a common cross-linking agent, glutaraldehyde, for the in-vitro release of cefadroxil. The beads formed were characterized by Fourier transform infra-red spectroscopy, scanning electron microscopy and differential scanning calorimetry. Swelling/drying experiments were performed to compute the diffusion coefficients and the molecular mass between cross-links of the beads. The release results were evaluated using an empirical equation to understand the transport mechanism. The extent of cross-linking was studied in terms of the size and release characteristics of the beads. The experimental and derived quantities have been used to study their dependencies on the nature of the polymeric beads, transport mechanism, encapsulation efficiency and drug diffusion, as well as the cross-linking abilities of the polymers.
ISSN:0939-6411
1873-3441
DOI:10.1016/S0939-6411(00)00150-8