Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing

The ventromedial nucleus (VMN) in animals is involved in a number of sexually dimorphic behaviors, including reproduction, and is a well-documented target for sex steroids. In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we det...

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Bibliographic Details
Published in:Brain research 2001-03, Vol.893 (1), p.70-76
Main Authors: Ishunina, T.A., Unmehopa, U.A., van Heerikhuize, J.J., Pool, C.W., Swaab, D.F.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Ageing
Aging - metabolism
Analysis of Variance
Antibody Specificity
Cell Size
Female
Golgi Apparatus - metabolism
Golgi Apparatus - ultrastructure
Human
Humans
Immunohistochemistry
Linear Models
Male
Menopause
Middle Aged
Neurons - metabolism
Neurons - ultrastructure
Sex Characteristics
Sex difference
Ventromedial Hypothalamic Nucleus - metabolism
Ventromedial Hypothalamic Nucleus - ultrastructure
Ventromedial nucleus
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Summary:The ventromedial nucleus (VMN) in animals is involved in a number of sexually dimorphic behaviors, including reproduction, and is a well-documented target for sex steroids. In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we determined whether the metabolic activity of human ventromedial nucleus neurons was sex- or age-related. The size of the immunocytochemically defined Golgi apparatus (GA) and cell profiles were determined as measures for neuronal metabolic activity in 12 male and 16 female control brains sub-divided into four groups with the dividing line being the age of 50. It appeared that the size of the GA relative to cell size was 34% larger in young women (
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(00)03289-3