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Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing
The ventromedial nucleus (VMN) in animals is involved in a number of sexually dimorphic behaviors, including reproduction, and is a well-documented target for sex steroids. In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we det...
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| Published in: | Brain research 2001-03, Vol.893 (1), p.70-76 |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_title | Brain research |
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| creator | Ishunina, T.A. Unmehopa, U.A. van Heerikhuize, J.J. Pool, C.W. Swaab, D.F. |
| description | The ventromedial nucleus (VMN) in animals is involved in a number of sexually dimorphic behaviors, including reproduction, and is a well-documented target for sex steroids. In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we determined whether the metabolic activity of human ventromedial nucleus neurons was sex- or age-related. The size of the immunocytochemically defined Golgi apparatus (GA) and cell profiles were determined as measures for neuronal metabolic activity in 12 male and 16 female control brains sub-divided into four groups with the dividing line being the age of 50. It appeared that the size of the GA relative to cell size was 34% larger in young women ( |
| doi_str_mv | 10.1016/S0006-8993(00)03289-3 |
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In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we determined whether the metabolic activity of human ventromedial nucleus neurons was sex- or age-related. The size of the immunocytochemically defined Golgi apparatus (GA) and cell profiles were determined as measures for neuronal metabolic activity in 12 male and 16 female control brains sub-divided into four groups with the dividing line being the age of 50. It appeared that the size of the GA relative to cell size was 34% larger in young women (<50 years old) than in young men and was 25% larger in elderly men (≥ 50 years old) than in young men. In addition, the GA/cell size ratio correlated significantly with age in men and not in women. Our data suggest that androgens play an inhibitory role with respect to the metabolic activity of the human VMN neurons.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(00)03289-3</identifier><identifier>PMID: 11222994</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Ageing ; Aging - metabolism ; Analysis of Variance ; Antibody Specificity ; Cell Size ; Female ; Golgi Apparatus - metabolism ; Golgi Apparatus - ultrastructure ; Human ; Humans ; Immunohistochemistry ; Linear Models ; Male ; Menopause ; Middle Aged ; Neurons - metabolism ; Neurons - ultrastructure ; Sex Characteristics ; Sex difference ; Ventromedial Hypothalamic Nucleus - metabolism ; Ventromedial Hypothalamic Nucleus - ultrastructure ; Ventromedial nucleus</subject><ispartof>Brain research, 2001-03, Vol.893 (1), p.70-76</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-43336f6251febdb06ca3b2a0dbef261325dc12e5de959836245931ce0c7b2c983</citedby><cites>FETCH-LOGICAL-c392t-43336f6251febdb06ca3b2a0dbef261325dc12e5de959836245931ce0c7b2c983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11222994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishunina, T.A.</creatorcontrib><creatorcontrib>Unmehopa, U.A.</creatorcontrib><creatorcontrib>van Heerikhuize, J.J.</creatorcontrib><creatorcontrib>Pool, C.W.</creatorcontrib><creatorcontrib>Swaab, D.F.</creatorcontrib><title>Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>The ventromedial nucleus (VMN) in animals is involved in a number of sexually dimorphic behaviors, including reproduction, and is a well-documented target for sex steroids. In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we determined whether the metabolic activity of human ventromedial nucleus neurons was sex- or age-related. The size of the immunocytochemically defined Golgi apparatus (GA) and cell profiles were determined as measures for neuronal metabolic activity in 12 male and 16 female control brains sub-divided into four groups with the dividing line being the age of 50. It appeared that the size of the GA relative to cell size was 34% larger in young women (<50 years old) than in young men and was 25% larger in elderly men (≥ 50 years old) than in young men. In addition, the GA/cell size ratio correlated significantly with age in men and not in women. Our data suggest that androgens play an inhibitory role with respect to the metabolic activity of the human VMN neurons.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Ageing</subject><subject>Aging - metabolism</subject><subject>Analysis of Variance</subject><subject>Antibody Specificity</subject><subject>Cell Size</subject><subject>Female</subject><subject>Golgi Apparatus - metabolism</subject><subject>Golgi Apparatus - ultrastructure</subject><subject>Human</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Linear Models</subject><subject>Male</subject><subject>Menopause</subject><subject>Middle Aged</subject><subject>Neurons - metabolism</subject><subject>Neurons - ultrastructure</subject><subject>Sex Characteristics</subject><subject>Sex difference</subject><subject>Ventromedial Hypothalamic Nucleus - metabolism</subject><subject>Ventromedial Hypothalamic Nucleus - ultrastructure</subject><subject>Ventromedial nucleus</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkE1PGzEQhi3UCgLtTwD5VMFh6djOeuMTQhFQpCAObS-9WF7vbHC1scH2Rs2_r_Oh9shpNKPnndE8hJwzuGbA5NfvACCrmVLiEuAKBJ-pShyRCZs1vJJ8Ch_I5B9yQk5T-l1aIRQckxPGOOdKTSfk1xNm04bBWWpsdmuXNzT0NL8gfRlXxtM1-hzDCjtnBupHO-CYqMcxBp-o8zTiYLILnuZAE_6hxnfULNH55SfysTdDws-HekZ-3t_9mH-rFs8Pj_PbRWWF4rmaCiFkL3nNemy7FqQ1ouUGuhZ7LpngdWcZx7pDVauZKK_VSjCLYJuW2zI5I1_2e19jeBsxZb1yyeIwGI9hTLoBWdfQyHdB1jQNTIEVsN6DNoaUIvb6NbqViRvNQG_t6519vVWrAfTOvhYld3E4MLbF2P_UQXcBbvYAFh9rh1En69DbYjeizboL7p0TfwGAXJSS</recordid><startdate>20010302</startdate><enddate>20010302</enddate><creator>Ishunina, T.A.</creator><creator>Unmehopa, U.A.</creator><creator>van Heerikhuize, J.J.</creator><creator>Pool, C.W.</creator><creator>Swaab, D.F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20010302</creationdate><title>Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing</title><author>Ishunina, T.A. ; Unmehopa, U.A. ; van Heerikhuize, J.J. ; Pool, C.W. ; Swaab, D.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-43336f6251febdb06ca3b2a0dbef261325dc12e5de959836245931ce0c7b2c983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Ageing</topic><topic>Aging - metabolism</topic><topic>Analysis of Variance</topic><topic>Antibody Specificity</topic><topic>Cell Size</topic><topic>Female</topic><topic>Golgi Apparatus - metabolism</topic><topic>Golgi Apparatus - ultrastructure</topic><topic>Human</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Linear Models</topic><topic>Male</topic><topic>Menopause</topic><topic>Middle Aged</topic><topic>Neurons - metabolism</topic><topic>Neurons - ultrastructure</topic><topic>Sex Characteristics</topic><topic>Sex difference</topic><topic>Ventromedial Hypothalamic Nucleus - metabolism</topic><topic>Ventromedial Hypothalamic Nucleus - ultrastructure</topic><topic>Ventromedial nucleus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishunina, T.A.</creatorcontrib><creatorcontrib>Unmehopa, U.A.</creatorcontrib><creatorcontrib>van Heerikhuize, J.J.</creatorcontrib><creatorcontrib>Pool, C.W.</creatorcontrib><creatorcontrib>Swaab, D.F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishunina, T.A.</au><au>Unmehopa, U.A.</au><au>van Heerikhuize, J.J.</au><au>Pool, C.W.</au><au>Swaab, D.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>2001-03-02</date><risdate>2001</risdate><volume>893</volume><issue>1</issue><spage>70</spage><epage>76</epage><pages>70-76</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>The ventromedial nucleus (VMN) in animals is involved in a number of sexually dimorphic behaviors, including reproduction, and is a well-documented target for sex steroids. In rats and in lizards, it is also characterized by the presence of structural sexual dimorphisms. In the present study, we determined whether the metabolic activity of human ventromedial nucleus neurons was sex- or age-related. The size of the immunocytochemically defined Golgi apparatus (GA) and cell profiles were determined as measures for neuronal metabolic activity in 12 male and 16 female control brains sub-divided into four groups with the dividing line being the age of 50. It appeared that the size of the GA relative to cell size was 34% larger in young women (<50 years old) than in young men and was 25% larger in elderly men (≥ 50 years old) than in young men. In addition, the GA/cell size ratio correlated significantly with age in men and not in women. 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| subjects | Adult Aged Aged, 80 and over Ageing Aging - metabolism Analysis of Variance Antibody Specificity Cell Size Female Golgi Apparatus - metabolism Golgi Apparatus - ultrastructure Human Humans Immunohistochemistry Linear Models Male Menopause Middle Aged Neurons - metabolism Neurons - ultrastructure Sex Characteristics Sex difference Ventromedial Hypothalamic Nucleus - metabolism Ventromedial Hypothalamic Nucleus - ultrastructure Ventromedial nucleus |
| title | Metabolic activity of the human ventromedial nucleus neurons in relation to sex and ageing |
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