Development of antral follicles in human cryopreserved ovarian tissue following xenografting

This study reports the first gross morphological and histological evidence of antral follicle development in human ovarian tissue following cryopreservation. Human ovarian tissue was cryopreserved using propanediol and sucrose and grafted under the renal capsule of bilaterally oophorectomized severe...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2001-03, Vol.16 (3), p.417-422
Main Authors: Gook, Debra A., McCully, B.A., Edgar, D.H., McBain, J.C.
Format: Article
Language:English
Subjects:
Animals
antral follicle
Biological and medical sciences
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cryopreservation
Female
Fundamental and applied biological sciences. Psychology
human
Humans
Mice
Mice, SCID
Molecular and cellular biology
Ovarian Follicle - anatomy & histology
Ovarian Follicle - cytology
Ovarian Follicle - physiology
Ovariectomy
ovary
Ovary - transplantation
transplantation
Transplantation, Heterologous
Transplantation, Heterotopic
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Summary:This study reports the first gross morphological and histological evidence of antral follicle development in human ovarian tissue following cryopreservation. Human ovarian tissue was cryopreserved using propanediol and sucrose and grafted under the renal capsule of bilaterally oophorectomized severe combined immunodeficient (SCID) mice. Follicles at all stages of development were observed in the grafted tissue whereas, prior to grafting, only primary and primordial follicles were present. Antral follicles were rarely observed on grafts examined
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/16.3.417