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Lymphoid cell infiltration into Epstein-Barr virus–positive nasopharyngeal carcinomas
Objectives: A pilot study was designed to analyze lymphoid cell infiltration in Epstein-Barr virus–positive (EBV +) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV + head and neck carcinomas or with solid EBV + tumors in other locatio...
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| Published in: | Otolaryngology-head and neck surgery 2001-02, Vol.124 (2), p.188-194 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 194 |
| container_issue | 2 |
| container_start_page | 188 |
| container_title | Otolaryngology-head and neck surgery |
| container_volume | 124 |
| creator | Shpitzer, Tommy Kerrebijn, Jeroen D.F. Freeman, Jeremy L. Hartwick, Warren Saiki, Yuriko Irish, Jonathan C. Macmillan, Christina M. Dosch, Hans-Michael |
| description | Objectives: A pilot study was designed to analyze lymphoid cell infiltration in Epstein-Barr virus–positive (EBV
+) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV
+ head and neck carcinomas or with solid EBV
+ tumors in other locations.
Study design: We performed a retrospective analysis of archived NPCs and oral cavity carcinomas.
Methods: Immunohistochemical staining of the archive material for various markers (CD3, CD8, UCHL-1, S-100, and intercellular adhesion molecule) was performed. Polymerase chain reaction techniques to establish the presence of the EBV genome were used. Cells in different locations were counted under a light microscope by 2 of the authors.
Results: The infiltration pattern of NPCs was different from that of oral cavity carcinomas. Stromal infiltration was significantly denser in oral cavity carcinomas. Tumor nest infiltration was more pronounced in NPCs. The pattern of infiltration was comparable with what has been described for other solid EBV
+ tumors.
Conclusions: The immune response to NPCs is likely to be strongly influenced by the presence of the EBV genome. The pattern of infiltration is similar to that of other non-head and neck EBV
+ solid tumors and different from that of EBV
− head and neck carcinomas. |
| doi_str_mv | 10.1067/mhn.2001.111711 |
| format | article |
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+) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV
+ head and neck carcinomas or with solid EBV
+ tumors in other locations.
Study design: We performed a retrospective analysis of archived NPCs and oral cavity carcinomas.
Methods: Immunohistochemical staining of the archive material for various markers (CD3, CD8, UCHL-1, S-100, and intercellular adhesion molecule) was performed. Polymerase chain reaction techniques to establish the presence of the EBV genome were used. Cells in different locations were counted under a light microscope by 2 of the authors.
Results: The infiltration pattern of NPCs was different from that of oral cavity carcinomas. Stromal infiltration was significantly denser in oral cavity carcinomas. Tumor nest infiltration was more pronounced in NPCs. The pattern of infiltration was comparable with what has been described for other solid EBV
+ tumors.
Conclusions: The immune response to NPCs is likely to be strongly influenced by the presence of the EBV genome. The pattern of infiltration is similar to that of other non-head and neck EBV
+ solid tumors and different from that of EBV
− head and neck carcinomas.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1067/mhn.2001.111711</identifier><identifier>PMID: 11226955</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Antigens, CD - metabolism ; Antigens, Viral - metabolism ; Carcinoma - genetics ; Carcinoma - metabolism ; Carcinoma - pathology ; Carcinoma - virology ; DNA, Viral - genetics ; Epstein-Barr Virus Infections - genetics ; Epstein-Barr Virus Infections - virology ; Genome, Viral ; Herpesvirus 4, Human - genetics ; Humans ; Immunohistochemistry ; Intercellular Adhesion Molecule-1 - genetics ; Intercellular Adhesion Molecule-1 - metabolism ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Nasopharyngeal Neoplasms - genetics ; Nasopharyngeal Neoplasms - metabolism ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - virology ; Pilot Projects ; Polymerase Chain Reaction ; Retrospective Studies ; S100 Proteins - metabolism</subject><ispartof>Otolaryngology-head and neck surgery, 2001-02, Vol.124 (2), p.188-194</ispartof><rights>2000 American Academy of Otolarynology - Head and Neck Surgery foundation, Inc.</rights><rights>2001 SAGE Publications</rights><rights>2001 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3824-dc3b8f3434bebbb50cd2ead3c572e04585904fcf4fab67b45bf7f0c9dd08a6183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11226955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shpitzer, Tommy</creatorcontrib><creatorcontrib>Kerrebijn, Jeroen D.F.</creatorcontrib><creatorcontrib>Freeman, Jeremy L.</creatorcontrib><creatorcontrib>Hartwick, Warren</creatorcontrib><creatorcontrib>Saiki, Yuriko</creatorcontrib><creatorcontrib>Irish, Jonathan C.</creatorcontrib><creatorcontrib>Macmillan, Christina M.</creatorcontrib><creatorcontrib>Dosch, Hans-Michael</creatorcontrib><title>Lymphoid cell infiltration into Epstein-Barr virus–positive nasopharyngeal carcinomas</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>Objectives: A pilot study was designed to analyze lymphoid cell infiltration in Epstein-Barr virus–positive (EBV
+) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV
+ head and neck carcinomas or with solid EBV
+ tumors in other locations.
Study design: We performed a retrospective analysis of archived NPCs and oral cavity carcinomas.
Methods: Immunohistochemical staining of the archive material for various markers (CD3, CD8, UCHL-1, S-100, and intercellular adhesion molecule) was performed. Polymerase chain reaction techniques to establish the presence of the EBV genome were used. Cells in different locations were counted under a light microscope by 2 of the authors.
Results: The infiltration pattern of NPCs was different from that of oral cavity carcinomas. Stromal infiltration was significantly denser in oral cavity carcinomas. Tumor nest infiltration was more pronounced in NPCs. The pattern of infiltration was comparable with what has been described for other solid EBV
+ tumors.
Conclusions: The immune response to NPCs is likely to be strongly influenced by the presence of the EBV genome. The pattern of infiltration is similar to that of other non-head and neck EBV
+ solid tumors and different from that of EBV
− head and neck carcinomas.</description><subject>Antigens, CD - metabolism</subject><subject>Antigens, Viral - metabolism</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - virology</subject><subject>DNA, Viral - genetics</subject><subject>Epstein-Barr Virus Infections - genetics</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Genome, Viral</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Intercellular Adhesion Molecule-1 - metabolism</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Nasopharyngeal Neoplasms - metabolism</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - virology</subject><subject>Pilot Projects</subject><subject>Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><subject>S100 Proteins - metabolism</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkM1u1DAURi1ERYfCmh3KihWZ2okdJ0tatRRp1G5asbT8c91xldjBTgbNjnfgDfsk9SgjsQJWV1c636d7D0IfCF4T3PDzYevXFcZkTQjhhLxCK4I7XjYt4a_RCpOOlqzr2lP0NqUnjHHTcP4GnRJSVU3H2Ap93-yHcRucKTT0feG8df0U5eSCz8sUiqsxTeB8eSFjLHYuzun51-8xJDe5HRRepjBuZdz7R5B9oWXUzodBpnfoxMo-wfvjPEMP11f3lzfl5u7rt8svm1LXbUVLo2vV2prWVIFSimFtKpCm1oxXgClrWYep1ZZaqRquKFOWW6w7Y3ArG9LWZ-jT0jvG8GOGNInBpcMr0kOYk-C4YZw3OIPnC6hjSCmCFWN0Q75cECwOLkV2KQ4uxeIyJz4eq2c1gPnDH-VlgC_AT9fD_n994u7m9uK64hWjOfl5SSb5COIpzNFnSf-4pFtwyCZ3DqJI2oHXYFwEPQkT3F-zLzMepJA</recordid><startdate>200102</startdate><enddate>200102</enddate><creator>Shpitzer, Tommy</creator><creator>Kerrebijn, Jeroen D.F.</creator><creator>Freeman, Jeremy L.</creator><creator>Hartwick, Warren</creator><creator>Saiki, Yuriko</creator><creator>Irish, Jonathan C.</creator><creator>Macmillan, Christina M.</creator><creator>Dosch, Hans-Michael</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200102</creationdate><title>Lymphoid cell infiltration into Epstein-Barr virus–positive nasopharyngeal carcinomas</title><author>Shpitzer, Tommy ; Kerrebijn, Jeroen D.F. ; Freeman, Jeremy L. ; Hartwick, Warren ; Saiki, Yuriko ; Irish, Jonathan C. ; Macmillan, Christina M. ; Dosch, Hans-Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3824-dc3b8f3434bebbb50cd2ead3c572e04585904fcf4fab67b45bf7f0c9dd08a6183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antigens, CD - metabolism</topic><topic>Antigens, Viral - metabolism</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - virology</topic><topic>DNA, Viral - genetics</topic><topic>Epstein-Barr Virus Infections - genetics</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Genome, Viral</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Intercellular Adhesion Molecule-1 - metabolism</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Nasopharyngeal Neoplasms - metabolism</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - virology</topic><topic>Pilot Projects</topic><topic>Polymerase Chain Reaction</topic><topic>Retrospective Studies</topic><topic>S100 Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shpitzer, Tommy</creatorcontrib><creatorcontrib>Kerrebijn, Jeroen D.F.</creatorcontrib><creatorcontrib>Freeman, Jeremy L.</creatorcontrib><creatorcontrib>Hartwick, Warren</creatorcontrib><creatorcontrib>Saiki, Yuriko</creatorcontrib><creatorcontrib>Irish, Jonathan C.</creatorcontrib><creatorcontrib>Macmillan, Christina M.</creatorcontrib><creatorcontrib>Dosch, Hans-Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shpitzer, Tommy</au><au>Kerrebijn, Jeroen D.F.</au><au>Freeman, Jeremy L.</au><au>Hartwick, Warren</au><au>Saiki, Yuriko</au><au>Irish, Jonathan C.</au><au>Macmillan, Christina M.</au><au>Dosch, Hans-Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphoid cell infiltration into Epstein-Barr virus–positive nasopharyngeal carcinomas</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2001-02</date><risdate>2001</risdate><volume>124</volume><issue>2</issue><spage>188</spage><epage>194</epage><pages>188-194</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>Objectives: A pilot study was designed to analyze lymphoid cell infiltration in Epstein-Barr virus–positive (EBV
+) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV
+ head and neck carcinomas or with solid EBV
+ tumors in other locations.
Study design: We performed a retrospective analysis of archived NPCs and oral cavity carcinomas.
Methods: Immunohistochemical staining of the archive material for various markers (CD3, CD8, UCHL-1, S-100, and intercellular adhesion molecule) was performed. Polymerase chain reaction techniques to establish the presence of the EBV genome were used. Cells in different locations were counted under a light microscope by 2 of the authors.
Results: The infiltration pattern of NPCs was different from that of oral cavity carcinomas. Stromal infiltration was significantly denser in oral cavity carcinomas. Tumor nest infiltration was more pronounced in NPCs. The pattern of infiltration was comparable with what has been described for other solid EBV
+ tumors.
Conclusions: The immune response to NPCs is likely to be strongly influenced by the presence of the EBV genome. The pattern of infiltration is similar to that of other non-head and neck EBV
+ solid tumors and different from that of EBV
− head and neck carcinomas.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>11226955</pmid><doi>10.1067/mhn.2001.111711</doi><tpages>7</tpages></addata></record> |
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| ispartof | Otolaryngology-head and neck surgery, 2001-02, Vol.124 (2), p.188-194 |
| issn | 0194-5998 1097-6817 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Antigens, CD - metabolism Antigens, Viral - metabolism Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Carcinoma - virology DNA, Viral - genetics Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - virology Genome, Viral Herpesvirus 4, Human - genetics Humans Immunohistochemistry Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Lymphocytes - metabolism Lymphocytes - pathology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - virology Pilot Projects Polymerase Chain Reaction Retrospective Studies S100 Proteins - metabolism |
| title | Lymphoid cell infiltration into Epstein-Barr virus–positive nasopharyngeal carcinomas |
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