Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B‐chronic lymphocytic leukaemia

Summary The occurrence of trisomy 19 was investigated in 705 cases of B‐chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1·6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV gen...

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Published in:British journal of haematology 2007-07, Vol.138 (2), p.217-220
Main Authors: Sellmann, Ludger, Gesk, Stefan, Walter, Christoph, Ritgen, Matthias, Harder, Lana, Martín‐Subero, José I., Schroers, Roland, Siemer, Dörte, Nückel, Holger, Dyer, Martin J.S., Dührsen, Ulrich, Siebert, Reiner, Dürig, Jan, Küppers, Ralf
Format: Article
Language:English
Subjects:
Biological and medical sciences
B‐chronic lymphocytic leukaemia
Chromosome aberrations
Chromosomes, Human, Pair 12 - genetics
Chromosomes, Human, Pair 19 - genetics
Cluster Analysis
cytogenetics
Female
Genes, Neoplasm - genetics
Hematologic and hematopoietic diseases
Humans
IgVH genes
Immunoglobulin Heavy Chains - genetics
Immunoglobulin Variable Region - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical genetics
Medical sciences
Middle Aged
Mutation
Trisomy - genetics
trisomy 12
trisomy 19
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Summary:Summary The occurrence of trisomy 19 was investigated in 705 cases of B‐chronic lymphocytic leukaemia (CLL) by metaphase cytogenetic and/or fluorescence in situ hybridisation analyses. Trisomy 19 was detected in 11 cases (1·6%), all of which also carried a trisomy 12; nine of 10 had mutated IGHV genes. In contrast, B‐CLL cases with trisomy 12 lacking trisomy 19 mostly had unmutated IGHV genes. Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B‐CLL with trisomy 12, mostly originating from mutated B cells.
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2007.06636.x