Metal complexes of cyclen and cyclam derivatives useful for medical applications: a discussion based on thermodynamic stability constants and structural data

A series of the most common chelators used in magnetic resonance imaging (MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic deriv...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2007-01 (26), p.2734-2745
Main Authors: Delgado, Rita, Félix, Vítor, Lima, Luís M P, Price, David W
Format: Article
Language:English
Subjects:
Chelating Agents - chemistry
Chelating Agents - therapeutic use
Heterocyclic Compounds - chemistry
Humans
Lanthanoid Series Elements - chemistry
Molecular Structure
Neoplasms - diagnostic imaging
Neoplasms - radiotherapy
Organometallic Compounds - chemistry
Organometallic Compounds - therapeutic use
Radionuclide Imaging
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - therapeutic use
Thermodynamics
Transition Elements - chemistry
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Summary:A series of the most common chelators used in magnetic resonance imaging (MRI) and in radiopharmaceuticals for medical diagnosis and tumour therapy, H(4)dota, H(4)teta, H(8)dotp and H(8)tetp, is examined from a chemical point of view. Differences between 12- and 14-membered tetraazamacrocyclic derivatives with methylcarboxylate and methylphosphonate pendant arms and their chelates with divalent first-series transition metal and trivalent lanthanide ions are discussed on the basis of their thermodynamic stability constants, X-ray structures and theoretical studies.
ISSN:1477-9226
1477-9234
DOI:10.1039/b704360k