Three-dimensional visualization of lung blood flow heterogeneity based on fluorescent microsphere technique and fractal dimension: The Blood Flow Analysis System — BFA System

The heterogeneity of regional pulmonary blood flow (RPBF) can be assessed by fractal analysis. The fractal dimension (FD) is a scale-independent measure of spatial heterogeneity of blood flow. The relative dispersion (RD) is often used to obtain the heterogeneity of RPBF but it is influenced by the...

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Bibliographic Details
Published in:Computer methods and programs in biomedicine 2001-04, Vol.65 (1), p.79-87
Main Authors: Bottino, D.A., Kleen, M., Kemming, G., Meisner, F., Habler, O., Messmer, K.
Format: Article
Language:English
Subjects:
3D lung reconstruction
Animals
Biological and medical sciences
Fluorescent Dyes
Fractal dimension
Fractals
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Lung - anatomy & histology
Lung - blood supply
Medical sciences
Microspheres
Miscellaneous
Models, Cardiovascular
Pulmonary blood flow
Pulmonary Circulation
Regional Blood Flow
Relative dispersion
Software
Spatial correlation
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Summary:The heterogeneity of regional pulmonary blood flow (RPBF) can be assessed by fractal analysis. The fractal dimension (FD) is a scale-independent measure of spatial heterogeneity of blood flow. The relative dispersion (RD) is often used to obtain the heterogeneity of RPBF but it is influenced by the resolution of measurement. The Blood Flow Analysis (BFA) System was developed in Delphi to represent the three-dimensional structure of lung blood flow and calculates statistics of FD, RD, spatial correlation of neighbored tissue samples and shows histograms of blood flows at diverse time points during different experiments. The BFA System reads a text file with flows, measured with fluorescent microsphere technique, and constructs the lung anatomy with volumetric pixels showing the flows with a color schema. It is possible to rotate the lungs into two axis ( XY) and the statistics are shown with 3D graphics. The System maintains a database with data from various studies at same time. The BFA System was validated with four data sets from previous experiments. The BFA System has shown consistency and it is a new tool to help researchers during lung perfusion studies.
ISSN:0169-2607
1872-7565
DOI:10.1016/S0169-2607(00)00115-2