Indole Alkaloids Produced by a Marine Fungus Isolate of Penicillium janthinellum Biourge

Three new indole alkaloids, shearinines D, E, and F (1−3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1−4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce a...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2007-06, Vol.70 (6), p.906-909
Main Authors: Smetanina, Olga F, Kalinovsky, Anatoly I, Khudyakova, Yuliya V, Pivkin, Mikhail V, Dmitrenok, Pavel S, Fedorov, Sergey N, Ji, Hong, Kwak, Jong-Young, Kuznetsova, Tatyana A
Format: Article
Language:English
Subjects:
Anticarcinogenic Agents - chemistry
Anticarcinogenic Agents - isolation & purification
Anticarcinogenic Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Apoptosis - drug effects
Drug Screening Assays, Antitumor
Humans
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Indole Alkaloids - pharmacology
Marine Biology
Molecular Structure
Penicillium - chemistry
Penicillium janthinellum
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Summary:Three new indole alkaloids, shearinines D, E, and F (1−3), together with the known shearinine A (4) were isolated from the marine-derived strain of the fungus Penicillium janthinellum Biourge. The chemical structures of 1−4 were established by 2D NMR and HREIMS data. Shearinines A, D, and E induce apoptosis in human leukemia HL-60 cells, and shearinine E also inhibits EGF-induced malignant transformation of JB6 P+ Cl 41 cells in a soft agar.
ISSN:0163-3864
1520-6025
DOI:10.1021/np060396d