Identification and characterization of two novel (neuro)endocrine long coiled-coil proteins

We have identified a novel vertebrate-specific gene by applying a Differential Display method on two distinct subtypes of pituitary melanotropes showing divergent secretory phenotypes of hypo- and hypersecretion. A paralogue of this gene was also identified. The existence of a long coiled-coil domai...

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Bibliographic Details
Published in:FEBS letters 2007-07, Vol.581 (17), p.3149-3156
Main Authors: Cruz-Garcia, D., Vazquez-Martinez, R., Peinado, J.R., Anouar, Y., Tonon, M.C., Vaudry, H., Castaño, J.P., Malagon, M.M.
Format: Article
Language:English
Subjects:
(Neuro)endocrine cells
Amino Acid Sequence
Animals
Cells, Cultured
Cloning
Cloning, Molecular
Gene expression
Gene Expression Profiling
Golgins
Humans
Long coiled-coil proteins
Melanotrophs - metabolism
Membrane Proteins - genetics
Membrane Proteins - metabolism
Molecular Sequence Data
Neurosecretory Systems - metabolism
Protein Structure, Tertiary - genetics
Rana ridibunda
Rats
Rats, Wistar
Secretory pathway
Sequence Homology, Amino Acid
Tissue Distribution
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Summary:We have identified a novel vertebrate-specific gene by applying a Differential Display method on two distinct subtypes of pituitary melanotropes showing divergent secretory phenotypes of hypo- and hypersecretion. A paralogue of this gene was also identified. The existence of a long coiled-coil domain and a C-terminal transmembrane domain in the sequences, together with the Golgi distribution of the proteins in transfected cells, suggest that they can be considered as new members of the golgin family of proteins. Both genes were primarily expressed in (neuro)endocrine tissues in vertebrates thus supporting a role for these proteins in the regulated secretory pathway.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2007.06.002