Tongue base metastasis from neuroendocrine endometrial small cell carcinoma

Abstract The endometrial small cell carcinoma (ESCC) is a rare and aggressive malignancy with an estimated prevalence of less than 1% of endometrial carcinomas. Endometrial small cell carcinoma is frequently diagnosed at an advanced stage and has a poor prognosis. Although the most common presenting...

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Bibliographic Details
Published in:American journal of otolaryngology 2007-07, Vol.28 (4), p.284-287
Main Authors: Marioni, Gino, MD, Savastano, Marina, MD, Mattiello, Laura, MD, Koussis, Haralabos, MD, Carpenè, Silvia, MD, Marino, Filippo, MD, Staffieri, Alberto, MD
Format: Article
Language:English
Subjects:
Abdomen
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Cancer
Carcinoma, Small Cell - diagnosis
Carcinoma, Small Cell - drug therapy
Carcinoma, Small Cell - secondary
Chemotherapy
Endometrial Neoplasms - diagnostic imaging
Endometrial Neoplasms - drug therapy
Endometrial Neoplasms - pathology
Family medical history
Fatal Outcome
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Hysterectomy
Magnetic Resonance Imaging
Medical imaging
Medical sciences
Middle Aged
Otolaryngology
Otorhinolaryngology. Stomatology
Surgery
Tomography
Tomography, X-Ray Computed
Tongue Neoplasms - diagnosis
Tongue Neoplasms - drug therapy
Tongue Neoplasms - secondary
Tumors
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Summary:Abstract The endometrial small cell carcinoma (ESCC) is a rare and aggressive malignancy with an estimated prevalence of less than 1% of endometrial carcinomas. Endometrial small cell carcinoma is frequently diagnosed at an advanced stage and has a poor prognosis. Although the most common presenting sign of ESCC is definitely a peri- or postmenopausal vaginal bleeding, we report for the first time the occurrence of tongue base bleeding as first manifestation of disseminated neuroendocrine ESCC. From a clinical viewpoint, tongue metastasis from primary endometrial carcinoma is a manifestation of widespread disease. Albeit, our patient underwent complete hysterectomy and postoperative chemotherapy, she died of disseminated disease 3 months after ESCC diagnosis.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2006.09.011