Orientia tsutsugamushi infection:overview and immune responses

Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi an...

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Bibliographic Details
Published in:Microbes and Infection 2001, Vol.3 (1), p.11-21
Main Authors: Seong, Seung-Yong, Choi, Myung-Sik, Kim, Ik-Sang
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Antigens, Bacterial - immunology
Australia
Bacterial diseases
Biological and medical sciences
Cytokines - biosynthesis
epidemiology
Human bacterial diseases
Humans
immune responses
Immunity, Cellular
Infectious diseases
inflammation
Inflammation - immunology
Japan
Medical sciences
Orientia tsutsugamushi
Orientia tsutsugamushi - immunology
Orientia tsutsugamushi - ultrastructure
Pakistan
Rickettsial diseases
Russia
Scrub Typhus - epidemiology
Scrub Typhus - immunology
Scrub Typhus - microbiology
Tropical bacterial diseases
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Summary:Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi and immune responses in terms of inflammation, protective immune mechanisms, and immunogenic antigens.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(00)01352-6