Polymorphisms of interleukin-10 and tumour necrosis factor-α genes are associated with newly diagnosed and recurrent pulmonary tuberculosis

Background and objectives:  The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor‐α (TNF‐α) and interleukin‐10 genes (IL‐10). Methods:  A case–control stud...

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Published in:Respirology (Carlton, Vic.) Vic.), 2007-07, Vol.12 (4), p.594-598
Main Authors: OH, Jae-Hee, YANG, Chul-Su, NOH, Yeon-Kyeong, KWEON, Yu-Mi, JUNG, Sung-Soo, SON, Ji Woong, KONG, Suck-Jun, YOON, Jang Uk, LEE, Ji-Sook, KIM, Hwa-Jung, PARK, Jeong-Kyu, JO, Eun-Kyeong, SONG, Chang-Hwa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Female
Genetic Predisposition to Disease - genetics
Genotype
Humans
interleukin-10
Interleukin-10 - genetics
Male
Middle Aged
Mycobacterium
newly diagnosed tuberculosis
Polymorphism, Genetic
Recurrence
recurrent tuberculosis
tuberculosis
Tuberculosis, Pulmonary - genetics
Tumor Necrosis Factor-alpha - genetics
tumour necrosis factor-α
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Summary:Background and objectives:  The genetic determinants for developing TB or having recurrent TB are unknown. The present study investigated the relationship between susceptibility to tuberculosis and human tumour necrosis factor‐α (TNF‐α) and interleukin‐10 genes (IL‐10). Methods:  A case–control study was conducted using two groups of cases—newly diagnosed TB (N‐TB) and recurrent TB (R‐TB)—and a control group. Results:  One hundred and seventeen healthy controls, 80 newly diagnosed TB patients and 65 patients with recurrent TB were enrolled. There was no significant difference in the TNF‐α−308 G/A genotype between the TB patient groups and the controls. The IL‐10 −1082A alleles were markedly over‐represented among the TB patient groups compared with the control subjects, however, there was no significant difference in the IL‐10 genotype frequency between the N‐TB and R‐TB patient groups. Conclusion:  The −1082A allele of the IL‐10 gene may be important in determining susceptibility to TB, however, the −308 allele of the TNF‐α gene does not affect differential TB susceptibility.
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2007.01108.x