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Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus infection
PURPOSE: To examine the cause of adult T-cell leukemia/lymphoma. METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, mi...
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| Published in: | American journal of ophthalmology 2001-03, Vol.131 (3), p.381-383 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 383 |
| container_issue | 3 |
| container_start_page | 381 |
| container_title | American journal of ophthalmology |
| container_volume | 131 |
| creator | Buggage, Ronald R Smith, Janine A Shen, DeFen Chan, Chi-Chao |
| description | PURPOSE: To examine the cause of adult T-cell leukemia/lymphoma.
METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction.
RESULTS:
Histopathologic examination revealed a conjunctival lymphoma. Clonality of the T-cell receptor gamma gene and human T-cell lymphotrophic virus gag gene were detected in the malignant cells. The demonstration of the human T-cell lymphotrophic virus gene and the rearrangement of the T-cell receptor gene in this neoplasm provide proof that human T-cell lymphotrophic virus is the cause of this conjunctival T-cell lymphoma.
CONCLUSION: Human T-cell lymphotrophic virus is the cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes. |
| doi_str_mv | 10.1016/S0002-9394(00)00865-5 |
| format | article |
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METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction.
RESULTS:
Histopathologic examination revealed a conjunctival lymphoma. Clonality of the T-cell receptor gamma gene and human T-cell lymphotrophic virus gag gene were detected in the malignant cells. The demonstration of the human T-cell lymphotrophic virus gene and the rearrangement of the T-cell receptor gene in this neoplasm provide proof that human T-cell lymphotrophic virus is the cause of this conjunctival T-cell lymphoma.
CONCLUSION: Human T-cell lymphotrophic virus is the cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(00)00865-5</identifier><identifier>PMID: 11239876</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; CD4-Positive T-Lymphocytes - virology ; Conjunctival Neoplasms - diagnosis ; Conjunctival Neoplasms - virology ; DNA, Neoplasm - analysis ; Gene Rearrangement, T-Lymphocyte - genetics ; Genes, gag - genetics ; Hematologic and hematopoietic diseases ; Human T-lymphotropic virus 1 - genetics ; Human T-lymphotropic virus 1 - isolation & purification ; Humans ; Leukemia-Lymphoma, Adult T-Cell - diagnosis ; Leukemia-Lymphoma, Adult T-Cell - virology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Polymerase Chain Reaction ; Receptors, Antigen, T-Cell, gamma-delta - genetics</subject><ispartof>American journal of ophthalmology, 2001-03, Vol.131 (3), p.381-383</ispartof><rights>2001 Elsevier Science Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-4de8591a062b9bc6a2f46626d4f1982958a09d9ea32acffa87acd8cb6f1a5b343</citedby><cites>FETCH-LOGICAL-c389t-4de8591a062b9bc6a2f46626d4f1982958a09d9ea32acffa87acd8cb6f1a5b343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=919803$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11239876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buggage, Ronald R</creatorcontrib><creatorcontrib>Smith, Janine A</creatorcontrib><creatorcontrib>Shen, DeFen</creatorcontrib><creatorcontrib>Chan, Chi-Chao</creatorcontrib><title>Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus infection</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>PURPOSE: To examine the cause of adult T-cell leukemia/lymphoma.
METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction.
RESULTS:
Histopathologic examination revealed a conjunctival lymphoma. Clonality of the T-cell receptor gamma gene and human T-cell lymphotrophic virus gag gene were detected in the malignant cells. The demonstration of the human T-cell lymphotrophic virus gene and the rearrangement of the T-cell receptor gene in this neoplasm provide proof that human T-cell lymphotrophic virus is the cause of this conjunctival T-cell lymphoma.
CONCLUSION: Human T-cell lymphotrophic virus is the cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>Conjunctival Neoplasms - diagnosis</subject><subject>Conjunctival Neoplasms - virology</subject><subject>DNA, Neoplasm - analysis</subject><subject>Gene Rearrangement, T-Lymphocyte - genetics</subject><subject>Genes, gag - genetics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Human T-lymphotropic virus 1 - genetics</subject><subject>Human T-lymphotropic virus 1 - isolation & purification</subject><subject>Humans</subject><subject>Leukemia-Lymphoma, Adult T-Cell - diagnosis</subject><subject>Leukemia-Lymphoma, Adult T-Cell - virology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - genetics</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkFlLAzEQgIMoth4_QVkQRB9WJ3tkkyeR4gUFEetzmM0mNGWPmnQL_femBxWffBqG-eb6CLmgcEeBsvtPAEhikYrsBuAWgLM8zg_IkPJCxJQLekiGe2RATryfhZQVWXFMBpQmqeAFG5KPUdfO-lYt7BLraBIrXddRvWrm067BSGHvdRWVq2jaN9j-rS9cN59aFS2t631kW6PDlK49I0cGa6_Pd_GUfD0_TUav8fj95W30OI5VysUizirNc0ERWFKKUjFMTMZYwqrMUMETkXMEUQmNaYLKGOQFqoqrkhmKeZlm6Sm53s6du-67134hG-vX52Gru97LAhjjSQYBzLegcp33Ths5d7ZBt5IU5Nql3LiUa1ESQG5cyjz0Xe4W9GWjq9-unbwAXO0A9Apr47BV1u85Ef6ANFAPW0oHGUurnfTK6lbpyrpgTFad_eeQH-rNkQQ</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Buggage, Ronald R</creator><creator>Smith, Janine A</creator><creator>Shen, DeFen</creator><creator>Chan, Chi-Chao</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus infection</title><author>Buggage, Ronald R ; Smith, Janine A ; Shen, DeFen ; Chan, Chi-Chao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-4de8591a062b9bc6a2f46626d4f1982958a09d9ea32acffa87acd8cb6f1a5b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Conjunctival Neoplasms - diagnosis</topic><topic>Conjunctival Neoplasms - virology</topic><topic>DNA, Neoplasm - analysis</topic><topic>Gene Rearrangement, T-Lymphocyte - genetics</topic><topic>Genes, gag - genetics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Human T-lymphotropic virus 1 - genetics</topic><topic>Human T-lymphotropic virus 1 - isolation & purification</topic><topic>Humans</topic><topic>Leukemia-Lymphoma, Adult T-Cell - diagnosis</topic><topic>Leukemia-Lymphoma, Adult T-Cell - virology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buggage, Ronald R</creatorcontrib><creatorcontrib>Smith, Janine A</creatorcontrib><creatorcontrib>Shen, DeFen</creatorcontrib><creatorcontrib>Chan, Chi-Chao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buggage, Ronald R</au><au>Smith, Janine A</au><au>Shen, DeFen</au><au>Chan, Chi-Chao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus infection</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>131</volume><issue>3</issue><spage>381</spage><epage>383</epage><pages>381-383</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>PURPOSE: To examine the cause of adult T-cell leukemia/lymphoma.
METHODS: We examined a conjunctival biopsy from a 29-year-old Jamaican man who developed bilateral conjunctival masses. Adult T-cell leukemia/lymphoma was diagnosed using routine histology, immunohistochemistry, electron microscopy, microdissection, and the polymerase chain reaction.
RESULTS:
Histopathologic examination revealed a conjunctival lymphoma. Clonality of the T-cell receptor gamma gene and human T-cell lymphotrophic virus gag gene were detected in the malignant cells. The demonstration of the human T-cell lymphotrophic virus gene and the rearrangement of the T-cell receptor gene in this neoplasm provide proof that human T-cell lymphotrophic virus is the cause of this conjunctival T-cell lymphoma.
CONCLUSION: Human T-cell lymphotrophic virus is the cause of adult T-cell leukemia/lymphoma, an aggressive malignancy of CD4+ lymphocytes.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11239876</pmid><doi>10.1016/S0002-9394(00)00865-5</doi><tpages>3</tpages></addata></record> |
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| source | Elsevier |
| subjects | Adult Biological and medical sciences Biopsy CD4-Positive T-Lymphocytes - virology Conjunctival Neoplasms - diagnosis Conjunctival Neoplasms - virology DNA, Neoplasm - analysis Gene Rearrangement, T-Lymphocyte - genetics Genes, gag - genetics Hematologic and hematopoietic diseases Human T-lymphotropic virus 1 - genetics Human T-lymphotropic virus 1 - isolation & purification Humans Leukemia-Lymphoma, Adult T-Cell - diagnosis Leukemia-Lymphoma, Adult T-Cell - virology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Polymerase Chain Reaction Receptors, Antigen, T-Cell, gamma-delta - genetics |
| title | Conjunctival T-cell lymphoma caused by human T-cell lymphotrophic virus infection |
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