Prevalence of antibody to hepatitis E virus among wild sika deer, Cervus nippon, in Japan

We examined 976 sika deer serum samples, 159 liver tissue samples and 88 stool samples collected from 16 prefectures in Japan, and performed ELISA and RT-PCR assays to detect antibodies to HEV and HEV RNA, respectively. Although 25 (2.6%) of 976 samples were positive for anti-HEV IgG, the antibody t...

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Bibliographic Details
Published in:Archives of virology 2007-07, Vol.152 (7), p.1375-1381
Main Authors: MATSUURA, Y, SUZUKI, M, BANDO, G, KOSUGE, M, TSUNEMITSU, H, KOSHIMOTO, C, SAKAE, K, CHIKAHIRA, M, OGAWA, S, MIYAMURA, T, TAKEDA, N, LI, T. C, YOSHIMATSU, K, ARIKAWA, J, TAKASHIMA, I, YOKOYAMA, M, IGOTA, H, YAMAUCHI, K, ISHIDA, S, FUKUI, D
Format: Article
Language:English
Subjects:
Animals
Antibodies
Base Sequence
Biological and medical sciences
Cervus nippon
Deer
Deer - immunology
Deer - virology
Disease Reservoirs - veterinary
Disease Reservoirs - virology
DNA Primers - genetics
DNA, Viral - genetics
Enzyme-linked immunosorbent assay
Epidemiology
Fundamental and applied biological sciences. Psychology
Genomes
Hepatitis
Hepatitis Antibodies - analysis
Hepatitis Antibodies - blood
Hepatitis E virus
Hepatitis E virus - immunology
Hepatitis, Viral, Animal - epidemiology
Hepatitis, Viral, Animal - immunology
Humans
Immunoglobulin G
Infections
Infectious diseases
Japan - epidemiology
Laboratories
Microbiology
Miscellaneous
Public health
Seroepidemiologic Studies
Species Specificity
Swine - virology
Veterinary colleges
Veterinary medicine
Virology
Viruses
Zoonoses
Zoonoses - epidemiology
Zoonoses - transmission
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Description
Summary:We examined 976 sika deer serum samples, 159 liver tissue samples and 88 stool samples collected from 16 prefectures in Japan, and performed ELISA and RT-PCR assays to detect antibodies to HEV and HEV RNA, respectively. Although 25 (2.6%) of 976 samples were positive for anti-HEV IgG, the antibody titers were very low. The OD values ranged between 0.018 and 0.486, forming a single distribution rather than a bimodal distribution, suggesting that the antibody detected in this study was not induced by HEV infection, or that deer have low sensitivity to HEV. HEV RNA was not detected in these samples, also suggesting that deer may not play a role as an HEV reservoir.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-007-0965-6