Mechanical properties of elastin along the thoracic aorta in the pig

Abstract Understanding the mechanical environment of each component within the arterial wall is fundamental for understanding vascular growth and remodelling and for engineering artificial vascular conduits. We have investigated the mechanical status of arterial elastin by measuring the circumferent...

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Bibliographic Details
Published in:Journal of biomechanics 2007-01, Vol.40 (10), p.2214-2221
Main Authors: Lillie, M.A, Gosline, J.M
Format: Article
Language:English
Subjects:
Animals
Anisotropy
Aorta
Aorta, Thoracic - anatomy & histology
Aorta, Thoracic - physiology
Blood Vessel Prosthesis
Elasticity
Elastin
Elastin - physiology
Mechanical properties
Models, Cardiovascular
Physical Medicine and Rehabilitation
Stress, Mechanical
Swine
Tissue engineering
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Summary:Abstract Understanding the mechanical environment of each component within the arterial wall is fundamental for understanding vascular growth and remodelling and for engineering artificial vascular conduits. We have investigated the mechanical status of arterial elastin by measuring the circumferential mechanical properties of purified elastin as function of position along the descending thoracic aorta of the pig. The tensile circumferential secant modulus, Esec , measured in uniaxial mechanical tests, increased 30% ( P
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2006.10.025