Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction

• Published in: European heart journal 2006-02, Vol.27 (3), p.283-289
• Main Authors: Wojakowski, Wojciech, Tendera, Michał, Zebzda, Anna, Michałowska, Anna, Majka, Marcin, Kucia, Magdalena, Maślankiewicz, Katarzyna, Wyderka, Rafał, Król, Marek, Ochała, Andrzej, Kozakiewicz, Krystyna, Ratajczak, Mariusz Z.
• Format: Article
• Language: English
• Subjects: Antigens, CD34 - metabolism; Biological and medical sciences; Biomarkers - metabolism; Blood cells; Cardiology. Vascular system; Coronary heart disease; Female; Heart; Hematopoietic Stem Cells - physiology; Humans; Inflammation; Left ventricular ejection fraction; Male; Medical sciences; Middle Aged; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - physiopathology; Myocarditis. Cardiomyopathies; Natriuretic Peptide, Brain - metabolism; Natriuretic peptides; Peptide Fragments - metabolism; Proto-Oncogene Proteins c-kit - metabolism; Proto-Oncogene Proteins c-met - metabolism; Receptors, Cell Surface - metabolism; Receptors, CXCR4 - metabolism; Stroke Volume
• ISSN: 0195-668X; 1522-9645
• DOI: 10.1093/eurheartj/ehi628

Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI). Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=−0.37; P=0.029 and r=−0.45, P=0.02) and maximum activity of CK-MB (r=−0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found. Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.