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Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction

Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI). Met...

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Published in:	European heart journal 2006-02, Vol.27 (3), p.283-289
Main Authors:	Wojakowski, Wojciech, Tendera, Michał, Zebzda, Anna, Michałowska, Anna, Majka, Marcin, Kucia, Magdalena, Maślankiewicz, Katarzyna, Wyderka, Rafał, Król, Marek, Ochała, Andrzej, Kozakiewicz, Krystyna, Ratajczak, Mariusz Z.
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Subjects:	Antigens, CD34 - metabolism Biological and medical sciences Biomarkers - metabolism Blood cells Cardiology. Vascular system Coronary heart disease Female Heart Hematopoietic Stem Cells - physiology Humans Inflammation Left ventricular ejection fraction Male Medical sciences Middle Aged Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocarditis. Cardiomyopathies Natriuretic Peptide, Brain - metabolism Natriuretic peptides Peptide Fragments - metabolism Proto-Oncogene Proteins c-kit - metabolism Proto-Oncogene Proteins c-met - metabolism Receptors, Cell Surface - metabolism Receptors, CXCR4 - metabolism Stroke Volume
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creator	Wojakowski, Wojciech Tendera, Michał Zebzda, Anna Michałowska, Anna Majka, Marcin Kucia, Magdalena Maślankiewicz, Katarzyna Wyderka, Rafał Król, Marek Ochała, Andrzej Kozakiewicz, Krystyna Ratajczak, Mariusz Z.
description	Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI). Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=−0.37; P=0.029 and r=−0.45, P=0.02) and maximum activity of CK-MB (r=−0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found. Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.
doi_str_mv	10.1093/eurheartj/ehi628
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Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (<12 h) in AMI was significantly, positively correlated with LVEF: r=0.49 (P=0.0012) for CD34+ cells, r=0.48 (P=0.0018) for CXCR4+ cells, r=0.45 (P=0.0043) for CD117+ cells, and r=0.41 (P=0.01) for c-met+ cells and negatively correlated with NT-proBNP levels on admission r=−0.35 (P=0.024) for CD34+ cells, r=−0.42 (P=0.007) for CXCR4+ cells, r=−0.33 (P=0.04). In patients with LVEF ≤40%, the peak number of CD34+, CXCR4+, CD117+, and c-met+ stem cells was significantly lower when compared patients with LVEF >40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=−0.37; P=0.029 and r=−0.45, P=0.02) and maximum activity of CK-MB (r=−0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found. Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1093/eurheartj/ehi628</identifier><identifier>PMID: 16267071</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Antigens, CD34 - metabolism ; Biological and medical sciences ; Biomarkers - metabolism ; Blood cells ; Cardiology. Vascular system ; Coronary heart disease ; Female ; Heart ; Hematopoietic Stem Cells - physiology ; Humans ; Inflammation ; Left ventricular ejection fraction ; Male ; Medical sciences ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - metabolism ; Myocardial Infarction - physiopathology ; Myocarditis. Cardiomyopathies ; Natriuretic Peptide, Brain - metabolism ; Natriuretic peptides ; Peptide Fragments - metabolism ; Proto-Oncogene Proteins c-kit - metabolism ; Proto-Oncogene Proteins c-met - metabolism ; Receptors, Cell Surface - metabolism ; Receptors, CXCR4 - metabolism ; Stroke Volume</subject><ispartof>European heart journal, 2006-02, Vol.27 (3), p.283-289</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Oxford University Press(England)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-168b25e7d71a0a32633e961cab601d8e349a1108ed86808ed10ee3f327add1943</citedby><cites>FETCH-LOGICAL-c465t-168b25e7d71a0a32633e961cab601d8e349a1108ed86808ed10ee3f327add1943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17447531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16267071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wojakowski, Wojciech</creatorcontrib><creatorcontrib>Tendera, Michał</creatorcontrib><creatorcontrib>Zebzda, Anna</creatorcontrib><creatorcontrib>Michałowska, Anna</creatorcontrib><creatorcontrib>Majka, Marcin</creatorcontrib><creatorcontrib>Kucia, Magdalena</creatorcontrib><creatorcontrib>Maślankiewicz, Katarzyna</creatorcontrib><creatorcontrib>Wyderka, Rafał</creatorcontrib><creatorcontrib>Król, Marek</creatorcontrib><creatorcontrib>Ochała, Andrzej</creatorcontrib><creatorcontrib>Kozakiewicz, Krystyna</creatorcontrib><creatorcontrib>Ratajczak, Mariusz Z.</creatorcontrib><title>Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI). Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (<12 h) in AMI was significantly, positively correlated with LVEF: r=0.49 (P=0.0012) for CD34+ cells, r=0.48 (P=0.0018) for CXCR4+ cells, r=0.45 (P=0.0043) for CD117+ cells, and r=0.41 (P=0.01) for c-met+ cells and negatively correlated with NT-proBNP levels on admission r=−0.35 (P=0.024) for CD34+ cells, r=−0.42 (P=0.007) for CXCR4+ cells, r=−0.33 (P=0.04). In patients with LVEF ≤40%, the peak number of CD34+, CXCR4+, CD117+, and c-met+ stem cells was significantly lower when compared patients with LVEF >40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=−0.37; P=0.029 and r=−0.45, P=0.02) and maximum activity of CK-MB (r=−0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found. Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.</description><subject>Antigens, CD34 - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Blood cells</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Female</subject><subject>Heart</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Left ventricular ejection fraction</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - metabolism</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Natriuretic Peptide, Brain - metabolism</subject><subject>Natriuretic peptides</subject><subject>Peptide Fragments - metabolism</subject><subject>Proto-Oncogene Proteins c-kit - metabolism</subject><subject>Proto-Oncogene Proteins c-met - metabolism</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Stroke Volume</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxSMEokvhzglZSHApoZ44seMjbIGCSilQpBUXa9aZaL3Nn8VOCuWL8fVwuqtW4sLp2fLvPc34Jclj4C-Ba3FIo18R-mF9SCsns_JOMoMiy1It8-JuMuOgi1TKcrGXPAhhzTkvJcj7yR7ITCquYJb8-dgvXeN-4-D6jvU1mx-J_OBFFAA16WL-ZbrbtKXhgIWBWmapaQJzgdnee2pwoIr9dMOKNVQP7JK6wTs7NugZrcleB9cetwfsKrZpMLTITs_Tje9fn55F3yVNiR3bxDmiP2zz0I4Dsfaqt-grh00kavTXQQ-TezU2gR7tdD_59vbN-fw4Pfn07v381Ulqc1kMKchymRWkKgXIUWRSCNISLC4lh6okkWsE4CVVpSwnAU4kapEprCrQudhPnm9z46g_RgqDaV2YPgA76sdgFJcq1wD_BUFrLbUuI_j0H3Ddj76LS5gMijxCmYgQ30LW9yF4qs3Guxb9lQFupurNTfVmW320PNnljsuWqlvDrusIPNsBGCw2sZLOunDLqTxXhZi4dMu52Pavm3f0F0YqoQpzvPhujs6KD18LKMxn8RdLV8kP</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>Wojakowski, Wojciech</creator><creator>Tendera, Michał</creator><creator>Zebzda, Anna</creator><creator>Michałowska, Anna</creator><creator>Majka, Marcin</creator><creator>Kucia, Magdalena</creator><creator>Maślankiewicz, Katarzyna</creator><creator>Wyderka, Rafał</creator><creator>Król, Marek</creator><creator>Ochała, Andrzej</creator><creator>Kozakiewicz, Krystyna</creator><creator>Ratajczak, Mariusz Z.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction</title><author>Wojakowski, Wojciech ; Tendera, Michał ; Zebzda, Anna ; Michałowska, Anna ; Majka, Marcin ; Kucia, Magdalena ; Maślankiewicz, Katarzyna ; Wyderka, Rafał ; Król, Marek ; Ochała, Andrzej ; Kozakiewicz, Krystyna ; Ratajczak, Mariusz Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-168b25e7d71a0a32633e961cab601d8e349a1108ed86808ed10ee3f327add1943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antigens, CD34 - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Blood cells</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Female</topic><topic>Heart</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Left ventricular ejection fraction</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - metabolism</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Natriuretic Peptide, Brain - metabolism</topic><topic>Natriuretic peptides</topic><topic>Peptide Fragments - metabolism</topic><topic>Proto-Oncogene Proteins c-kit - metabolism</topic><topic>Proto-Oncogene Proteins c-met - metabolism</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Stroke Volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wojakowski, Wojciech</creatorcontrib><creatorcontrib>Tendera, Michał</creatorcontrib><creatorcontrib>Zebzda, Anna</creatorcontrib><creatorcontrib>Michałowska, Anna</creatorcontrib><creatorcontrib>Majka, Marcin</creatorcontrib><creatorcontrib>Kucia, Magdalena</creatorcontrib><creatorcontrib>Maślankiewicz, Katarzyna</creatorcontrib><creatorcontrib>Wyderka, Rafał</creatorcontrib><creatorcontrib>Król, Marek</creatorcontrib><creatorcontrib>Ochała, Andrzej</creatorcontrib><creatorcontrib>Kozakiewicz, Krystyna</creatorcontrib><creatorcontrib>Ratajczak, Mariusz Z.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wojakowski, Wojciech</au><au>Tendera, Michał</au><au>Zebzda, Anna</au><au>Michałowska, Anna</au><au>Majka, Marcin</au><au>Kucia, Magdalena</au><au>Maślankiewicz, Katarzyna</au><au>Wyderka, Rafał</au><au>Król, Marek</au><au>Ochała, Andrzej</au><au>Kozakiewicz, Krystyna</au><au>Ratajczak, Mariusz Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>27</volume><issue>3</issue><spage>283</spage><epage>289</epage><pages>283-289</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims The aim of the study was to assess the correlation between the number of CD34+, CD117+, c-met+, CXCR4+ stem cells mobilized into peripheral blood, left ventricular ejection fraction (LVEF), NT-proBNP levels, and myocardial necrosis markers in patients with acute myocardial infarction (AMI). Methods and results 43 patients with STEMI were enrolled. Stem cells number was measured using flow-cytometer and concentrations of NT-proBNP, SDF-1, G-CSF, VEGF, IL-6, and HGF were measured using ELISA kits. The number of stem cells mobilized early (<12 h) in AMI was significantly, positively correlated with LVEF: r=0.49 (P=0.0012) for CD34+ cells, r=0.48 (P=0.0018) for CXCR4+ cells, r=0.45 (P=0.0043) for CD117+ cells, and r=0.41 (P=0.01) for c-met+ cells and negatively correlated with NT-proBNP levels on admission r=−0.35 (P=0.024) for CD34+ cells, r=−0.42 (P=0.007) for CXCR4+ cells, r=−0.33 (P=0.04). In patients with LVEF ≤40%, the peak number of CD34+, CXCR4+, CD117+, and c-met+ stem cells was significantly lower when compared patients with LVEF >40%. The number of CXCR4+ cells on admission and after 24 h was negatively correlated with respective cardiac Troponin I levels (r=−0.37; P=0.029 and r=−0.45, P=0.02) and maximum activity of CK-MB (r=−0.37; P=0.021). No significant correlations between levels of haematopoietic cytokines and LVEF were found. Conclusion The mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells into peripheral blood early in STEMI is positively correlated with LVEF and negatively correlated with NT-proBNP levels and myocardial necrosis markers.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>16267071</pmid><doi>10.1093/eurheartj/ehi628</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
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subjects	Antigens, CD34 - metabolism Biological and medical sciences Biomarkers - metabolism Blood cells Cardiology. Vascular system Coronary heart disease Female Heart Hematopoietic Stem Cells - physiology Humans Inflammation Left ventricular ejection fraction Male Medical sciences Middle Aged Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocarditis. Cardiomyopathies Natriuretic Peptide, Brain - metabolism Natriuretic peptides Peptide Fragments - metabolism Proto-Oncogene Proteins c-kit - metabolism Proto-Oncogene Proteins c-met - metabolism Receptors, Cell Surface - metabolism Receptors, CXCR4 - metabolism Stroke Volume
title	Mobilization of CD34+, CD117+, CXCR4+, c-met+ stem cells is correlated with left ventricular ejection fraction and plasma NT-proBNP levels in patients with acute myocardial infarction
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