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The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis : 1-year, single-blind, randomized study
The goal of this study was to assess the safety and efficacy of hyaluronan (HA) with/without corticosteroid in patients with knee osteoarthritis (OA). In a 1-year, randomized, single-blind trial, 24 patients were treated with HA weekly for 3 weeks, then three injections on the 6th month for a total...
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| Published in: | Rheumatology international 2006-02, Vol.26 (4), p.314-319 |
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| creator | OZTURK, Cihat ATAMAZ, Funda HEPGULER, Simin ARGIN, Mehmet ARKUN, Remide |
| description | The goal of this study was to assess the safety and efficacy of hyaluronan (HA) with/without corticosteroid in patients with knee osteoarthritis (OA). In a 1-year, randomized, single-blind trial, 24 patients were treated with HA weekly for 3 weeks, then three injections on the 6th month for a total of six injections. Sixteen patients were treated the same but with the addition of 1 ml triamcinolone acetonide prior to the first and fourth HA injection. The treatment was repeated at the sixth month. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). After 1 year, progression of OA was evaluated with magnetic resonance imaging (MRI). During the study, pain relief was marked in patients who received combined treatment with respect to WOMAC pain and VAS (p |
| doi_str_mv | 10.1007/s00296-005-0584-z |
| format | article |
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In a 1-year, randomized, single-blind trial, 24 patients were treated with HA weekly for 3 weeks, then three injections on the 6th month for a total of six injections. Sixteen patients were treated the same but with the addition of 1 ml triamcinolone acetonide prior to the first and fourth HA injection. The treatment was repeated at the sixth month. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). After 1 year, progression of OA was evaluated with magnetic resonance imaging (MRI). During the study, pain relief was marked in patients who received combined treatment with respect to WOMAC pain and VAS (p<0.05). At the first year, no progression was observed in either treatment group. Although all patients had improvement for both pain and function, HA together with corticosteroid was superior to HA alone for early pain relief. The MRI findings showed that neither treatment showed a progression on the damage of the cartilage.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-005-0584-z</identifier><identifier>PMID: 15703953</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Adjuvants, Immunologic - therapeutic use ; Arthritis ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Diseases of the osteoarticular system ; Drug Therapy, Combination ; Female ; Glucocorticoids - therapeutic use ; Humans ; Hyaluronic Acid - administration & dosage ; Hyaluronic Acid - therapeutic use ; Injections, Intra-Articular ; Knee Joint - pathology ; Knee Joint - physiopathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Miscellaneous. Osteoarticular involvement in other diseases ; Osteoarthritis ; Osteoarthritis, Knee - drug therapy ; Osteoarthritis, Knee - pathology ; Osteoarthritis, Knee - physiopathology ; Pain ; Pain - drug therapy ; Pain - physiopathology ; Pharmacology. Drug treatments ; Range of Motion, Articular - drug effects ; Severity of Illness Index ; Single-Blind Method ; Treatment Outcome ; Triamcinolone Acetonide - therapeutic use</subject><ispartof>Rheumatology international, 2006-02, Vol.26 (4), p.314-319</ispartof><rights>2006 INIST-CNRS</rights><rights>Springer-Verlag 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-5d547fea9a6ed76c5c2015aaa5d68247198a2918d1f9bc81d5c80321e978a71a3</citedby><cites>FETCH-LOGICAL-c356t-5d547fea9a6ed76c5c2015aaa5d68247198a2918d1f9bc81d5c80321e978a71a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17481270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15703953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OZTURK, Cihat</creatorcontrib><creatorcontrib>ATAMAZ, Funda</creatorcontrib><creatorcontrib>HEPGULER, Simin</creatorcontrib><creatorcontrib>ARGIN, Mehmet</creatorcontrib><creatorcontrib>ARKUN, Remide</creatorcontrib><title>The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis : 1-year, single-blind, randomized study</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><description>The goal of this study was to assess the safety and efficacy of hyaluronan (HA) with/without corticosteroid in patients with knee osteoarthritis (OA). In a 1-year, randomized, single-blind trial, 24 patients were treated with HA weekly for 3 weeks, then three injections on the 6th month for a total of six injections. Sixteen patients were treated the same but with the addition of 1 ml triamcinolone acetonide prior to the first and fourth HA injection. The treatment was repeated at the sixth month. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). After 1 year, progression of OA was evaluated with magnetic resonance imaging (MRI). During the study, pain relief was marked in patients who received combined treatment with respect to WOMAC pain and VAS (p<0.05). At the first year, no progression was observed in either treatment group. Although all patients had improvement for both pain and function, HA together with corticosteroid was superior to HA alone for early pain relief. The MRI findings showed that neither treatment showed a progression on the damage of the cartilage.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Adjuvants, Immunologic - therapeutic use</subject><subject>Arthritis</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Diseases of the osteoarticular system</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Glucocorticoids - therapeutic use</subject><subject>Humans</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Injections, Intra-Articular</subject><subject>Knee Joint - pathology</subject><subject>Knee Joint - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - drug therapy</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Pain</subject><subject>Pain - drug therapy</subject><subject>Pain - physiopathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Range of Motion, Articular - drug effects</subject><subject>Severity of Illness Index</subject><subject>Single-Blind Method</subject><subject>Treatment Outcome</subject><subject>Triamcinolone Acetonide - therapeutic use</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpdkcuKFDEUhoMoTtv6AG4kCLqaOElV5VLuZPAGA25GcBdO52JnrE7GJIVUP4WPbIpuGHBzQsL3nxPOh9BLRt8xSuVVobQbBaGUE8rVQI6P0IYNvSRM0B-P0YYy2RHVygV6VsodbXch6FN0wbik_cj7Dfp7u3e4gHd1wRAtdt4HA2bByeMQawbINZh5goz3C0xzThEi_hPq_motaa7YpBVJpbqcgm0p_Cs6h9eH1NL7HGoo-D1mZHGQL3EJ8efkyG4K0V7i3KamQzg6i0ud7fIcPfEwFffifG7R908fb6-_kJtvn79ef7ghpueiEm75IL2DEYSzUhhuOso4AHArVDdINiroRqYs8-POKGa5UbTvmBulAsmg36K3p773Of2eXan6EIpx0wTRpbloSYXkvRwa-Po_8C7NOba_aaUG1gvadrlF7ASZnErJzuv7HA6QF82oXl3pkyvdXOnVlT62zKtz43l3cPYhcZbTgDdnAIqBybdVmVAeODko1jX2H6ivnwA</recordid><startdate>20060201</startdate><enddate>20060201</enddate><creator>OZTURK, Cihat</creator><creator>ATAMAZ, Funda</creator><creator>HEPGULER, Simin</creator><creator>ARGIN, Mehmet</creator><creator>ARKUN, Remide</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20060201</creationdate><title>The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis : 1-year, single-blind, randomized study</title><author>OZTURK, Cihat ; ATAMAZ, Funda ; HEPGULER, Simin ; ARGIN, Mehmet ; ARKUN, Remide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-5d547fea9a6ed76c5c2015aaa5d68247198a2918d1f9bc81d5c80321e978a71a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Adjuvants, Immunologic - therapeutic use</topic><topic>Arthritis</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Diseases of the osteoarticular system</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Glucocorticoids - therapeutic use</topic><topic>Humans</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Injections, Intra-Articular</topic><topic>Knee Joint - pathology</topic><topic>Knee Joint - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - drug therapy</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Pain</topic><topic>Pain - drug therapy</topic><topic>Pain - physiopathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Range of Motion, Articular - drug effects</topic><topic>Severity of Illness Index</topic><topic>Single-Blind Method</topic><topic>Treatment Outcome</topic><topic>Triamcinolone Acetonide - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OZTURK, Cihat</creatorcontrib><creatorcontrib>ATAMAZ, Funda</creatorcontrib><creatorcontrib>HEPGULER, Simin</creatorcontrib><creatorcontrib>ARGIN, Mehmet</creatorcontrib><creatorcontrib>ARKUN, Remide</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OZTURK, Cihat</au><au>ATAMAZ, Funda</au><au>HEPGULER, Simin</au><au>ARGIN, Mehmet</au><au>ARKUN, Remide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis : 1-year, single-blind, randomized study</atitle><jtitle>Rheumatology international</jtitle><addtitle>Rheumatol Int</addtitle><date>2006-02-01</date><risdate>2006</risdate><volume>26</volume><issue>4</issue><spage>314</spage><epage>319</epage><pages>314-319</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>The goal of this study was to assess the safety and efficacy of hyaluronan (HA) with/without corticosteroid in patients with knee osteoarthritis (OA). In a 1-year, randomized, single-blind trial, 24 patients were treated with HA weekly for 3 weeks, then three injections on the 6th month for a total of six injections. Sixteen patients were treated the same but with the addition of 1 ml triamcinolone acetonide prior to the first and fourth HA injection. The treatment was repeated at the sixth month. The patients were evaluated with the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the visual analog pain scale (VAS). After 1 year, progression of OA was evaluated with magnetic resonance imaging (MRI). During the study, pain relief was marked in patients who received combined treatment with respect to WOMAC pain and VAS (p<0.05). At the first year, no progression was observed in either treatment group. Although all patients had improvement for both pain and function, HA together with corticosteroid was superior to HA alone for early pain relief. The MRI findings showed that neither treatment showed a progression on the damage of the cartilage.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>15703953</pmid><doi>10.1007/s00296-005-0584-z</doi><tpages>6</tpages></addata></record> |
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| ispartof | Rheumatology international, 2006-02, Vol.26 (4), p.314-319 |
| issn | 0172-8172 1437-160X |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - therapeutic use Arthritis Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Diseases of the osteoarticular system Drug Therapy, Combination Female Glucocorticoids - therapeutic use Humans Hyaluronic Acid - administration & dosage Hyaluronic Acid - therapeutic use Injections, Intra-Articular Knee Joint - pathology Knee Joint - physiopathology Magnetic Resonance Imaging Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis, Knee - drug therapy Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Pain Pain - drug therapy Pain - physiopathology Pharmacology. Drug treatments Range of Motion, Articular - drug effects Severity of Illness Index Single-Blind Method Treatment Outcome Triamcinolone Acetonide - therapeutic use |
| title | The safety and efficacy of intraarticular hyaluronan with/without corticosteroid in knee osteoarthritis : 1-year, single-blind, randomized study |
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