Hypoglycaemic activity of Pterocarpus marsupium Roxb

The antidiabetic activity of various subfractions of the alcohol extract of the bark of Pterocarpus marsupium Roxb. was evaluated in alloxan‐induced diabetic rats. The effect of these extracts on lipid profile and liver function tests were also assessed to evaluate their activity in controlling diab...

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Bibliographic Details
Published in:Phytotherapy research 2006, Vol.20 (1), p.4-8
Main Authors: Dhanabal, S.P, Kokate, C.K, Ramanathan, M, Kumar, E.P, Suresh, B
Format: Article
Language:English
Subjects:
alloxan
Animals
antidiabetic activity
Biological and medical sciences
Blood Glucose - drug effects
Blood Glucose - metabolism
Blood Proteins - drug effects
Diabetes Mellitus, Experimental - drug therapy
General pharmacology
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
lipid profile
Lipids - blood
Liver - drug effects
Liver - physiopathology
Liver Function Tests
liver functions
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Bark - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Pterocarpus
Pterocarpus marsupium Roxb
Rats
Solvents
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Summary:The antidiabetic activity of various subfractions of the alcohol extract of the bark of Pterocarpus marsupium Roxb. was evaluated in alloxan‐induced diabetic rats. The effect of these extracts on lipid profile and liver function tests were also assessed to evaluate their activity in controlling diabetes related metabolic alterations. The parameters measured were plasma glucose, total protein, cholesterol, triglycerides, alkaline phosphatase, SGOT and SGPT. The results indicate the effective role of Pterocarpus marsupium on the above mentioned parameters indicating that Pterocarpus marsupium can also control the diabetes related metabolic alterations apart from controlling the glucose levels. Among the fractions tested the butanol subfraction was found to be more active in comparison with other subfractions. It can be concluded that the butanol subfraction of the alcohol extract of Pterocarpus marsupium exhibits significant antidiabetic activity and corrects the metabolic alterations in diabetic rats and this activity may resemble insulin‐like properties. Copyright © 2006 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1819