Cell lineage of the subcommissural organ secretory ependymocytes: Differentiating role of the environment

SCO‐ependymocytes have a secretory activity and a neural innervation relating them to neurosecretory nerve cells. To elucidate the cell lineage of the SCO‐ependymocytes and emphasize the role of the neural innervation in their differentiation, in particular 5‐HT innervation, we analyzed the developm...

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Published in:Microscopy research and technique 2001-03, Vol.52 (5), p.461-467
Main Authors: Didier-Bazès, Marianne, Chouaf-Lakhdar, Latifa, Dutuit, Magali, Aguera, Michèle, Belin, Marie-Françoise
Format: Article
Language:English
Subjects:
Animals
Cats
Cell Differentiation - physiology
Ependyma - cytology
ependymocytes
GABA uptake
gamma-Aminobutyric Acid - metabolism
GFAP
Glial Fibrillary Acidic Protein - metabolism
Mammalia
Mice
Neurons - physiology
rab GTP-Binding Proteins - metabolism
Rabbits
Rats
S100 protein
subcommissural organ
Subcommissural Organ - cytology
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Summary:SCO‐ependymocytes have a secretory activity and a neural innervation relating them to neurosecretory nerve cells. To elucidate the cell lineage of the SCO‐ependymocytes and emphasize the role of the neural innervation in their differentiation, in particular 5‐HT innervation, we analyzed the developmental pattern of expression of several glial and neuronal markers: (1) in the SCO of mammals possessing (rat, cat) or devoid (mouse, rabbit) of 5‐HT innervation, (2) in rat 5‐HT deafferented SCO, and (3) in rat SCO transplanted in a foreign environment, the fourth ventricle. The ability of SCO‐ependymocytes to transiently express GFAP during development and express the glial αα‐enolase confirms the glial lineage of the SCO‐ependymocytes. Synthesis of vimentin by SCO‐ependymocytes relates them to the classical ependymocytes. The ability of mature SCO‐ependymocytes to take up GABA only when they are innervated by 5‐HT terminal underlines the role of the neural environment on the differentiation of these ependymocytes and suggests that differential maturation of the SCO according to its innervation, may lead to specific functional specialization of this organ in different species. Microsc. Res. Tech. 52:461–467, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:1059-910X
1097-0029
DOI:10.1002/1097-0029(20010301)52:5<461::AID-JEMT1032>3.0.CO;2-H