Collection of hyperconcentrated platelets with Trima Accel

Background and Objectives  Lowering the plasma content in single‐donor platelet (PLT) concentrates well below 30% implies the need to collect platelets at very high concentrations. Trima Accel (TA) is validated for collection below 4000 × 103 PLTs/µl. We evaluated its performance at 5000 × 103 PLTs/...

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Bibliographic Details
Published in:Vox sanguinis 2006-02, Vol.90 (2), p.92-96
Main Authors: Ringwald, J., Duerler, T., Frankow, O., Zimmermann, R., Zingsem, J., Strasser, E., Antoon, M., Eckstein, R.
Format: Article
Language:English
Subjects:
Blood & organ donations
Blood products
collection efficiency
Humans
Medical equipment
platelet additive solutions
Platelet Count
plateletapheresis
Plateletpheresis - instrumentation
Plateletpheresis - methods
Plateletpheresis - statistics & numerical data
productivity
Software
Trima Accel
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Summary:Background and Objectives  Lowering the plasma content in single‐donor platelet (PLT) concentrates well below 30% implies the need to collect platelets at very high concentrations. Trima Accel (TA) is validated for collection below 4000 × 103 PLTs/µl. We evaluated its performance at 5000 × 103 PLTs/µl. Materials and Methods  Twenty blood donors underwent apheresis with TA twice collecting either a hyperconcentrated or a standard single‐donor platelet concentrate with a target platelet concentration of 5000 or 1200 × 103 PLTs/µl, respectively. We analysed the collection efficiency, the collection rate and the quality of the collected by‐plasma. Results  We collected 20 hyperconcentrated and 20 standard units containing 2·56 ± 0·5 and 3·39 ± 0·4 × 1011 PLTs at a concentration of 4518 ± 978 and 1374 ± 166 × 103 PLTs/µl in 45 ± 8 and 39 ± 6 min resulting in a collection efficiency of 47·5 ± 10·0 and 70·7 ± 7·9% and a collection rate of 5·9 ± 1·4 and 8·8 ± 1·5 × 109 PLTs/min, respectively (all results expressed as mean ± standard deviation). The collected by‐plasma showed a very high grade of cell purity and a satisfactory recovery of the clotting factors. Conclusion  Although TA is a suitable device for PLT collection at very high concentrations, improvements are desirable to further increase the productivity above its currently validated upper collect concentration limit.
ISSN:0042-9007
1423-0410
DOI:10.1111/j.1423-0410.2005.00721.x