A new cytotoxic phenazine derivative from a deep sea bacterium Bacillus sp

A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spect...

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Bibliographic Details
Published in:Archives of pharmacal research 2007-05, Vol.30 (5), p.552-555
Main Authors: Li, Dehai, Wang, Fengping, Xiao, Xiang, Zeng, Xiang, Gu, Qian-Qun, Zhu, Weiming
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - isolation & purification
Bacillus - chemistry
Humans
K562 Cells
Leukemia P388
Magnetic Resonance Spectroscopy
Mice
Phenazines - chemistry
Phenazines - isolation & purification
Phenazines - pharmacology
Water Microbiology
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Summary:A novel phenazine derivative (1) together with six known compounds (2-7) were isolated by bioassay-guided fractionation from the culture broth of a bacterium, Bacillus sp., collected from a Pacific deep sea sediment sample (depth 5059 m). The structures of these compounds were determined using spectroscopic methods. Their cytotoxic effects on P388 and K562 cell lines were preliminarily examined using the sulforhodamine-B (SRB) assay.
ISSN:0253-6269
DOI:10.1007/BF02977647