Is Compensatory Vasoconstrictor Tone in the Hindquarter Vascular Region Induced by Hemorrhage in Conscious Spontaneously Hypertensive Rats?

We investigated whether a compensatory vasoconstrictor action would be induced by a hypotensive intervention in the hindquarter vascular region of conscious spontaneously hypertensive rats (SHRs). Mean arterial pressure and hindquarter blood flow were recorded. After hemorrhage (withdrawing blood, 0...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 2001, Vol.85(1), pp.109-113
Main Authors: Teranishi, Yasuhiro, Iida, Noriko, Ishioka, Norio, Sugino, Hiroshi, Amano, Taku
Format: Article
Language:English
Subjects:
Animals
Aorta, Abdominal
Blood Flow Velocity
Blood Pressure - physiology
Consciousness
Ganglionic Blockers - pharmacology
Hemorrhage
Hemorrhage - physiopathology
Hexamethonium - pharmacology
Hindlimb - blood supply
Hindquarter compensator
Hypotension - physiopathology
Male
Rats
Rats, Inbred SHR
Rats, Wistar
Regional Blood Flow - physiology
Spontaneously hypertensive rat
Vascular Resistance - drug effects
Vascular Resistance - physiology
Vasoconstriction - physiology
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Summary:We investigated whether a compensatory vasoconstrictor action would be induced by a hypotensive intervention in the hindquarter vascular region of conscious spontaneously hypertensive rats (SHRs). Mean arterial pressure and hindquarter blood flow were recorded. After hemorrhage (withdrawing blood, 0.3 ml/100 g body weight), hindquarter resistance (HQR) was increased significantly. The decrease in HQR induced by the administration of a ganglionic blocker (C6; 25 mg/kg, i.v.) was significantly greater in SHRs with hemorrhage than in those without hemorrhage. The present results suggest that a detectable hindquarter compensator tone occurs due to hemorrhage in SHRs, although an abnormal substantial vasoconstrictor tone already exists in the hindquarters.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.85.109