Cladobotric Acids A−F:  New Cytotoxic Polyketides from a New Zealand Cladobotryum sp

• Published in: Journal of organic chemistry 2006-01, Vol.71 (2), p.492-497
• Main Authors: Mitova, Maya I, Lang, Gerhard, Blunt, John W, Cummings, Nicholas J, Cole, Anthony L. J, Robinson, Ward T, Munro, Murray H. G
• Format: Article
• Language: English
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Aromatic and heterocyclic compounds; Biological and medical sciences; Botrytis - chemistry; Botrytis - isolation & purification; Chemistry; Condensed benzenic and aromatic compounds; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; Heterocyclic compounds, pigments; Leukemia P388; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Molecular Conformation; New Zealand; Organic chemistry; Other biological molecules; Preparations and properties
• ISSN: 0022-3263; 1520-6904
• DOI: 10.1021/jo051883l

Cladobotric acids A−F (1−6), fungal-derived polyketides, were isolated from the fermentation broth of a New Zealand Cladobotryum species. Structures were determined by extensive spectral analysis and X-ray crystallography, and the polyketide origin of 1−6 was concluded from feeding experiments with 13C-labeled precursors. The observed folding pattern for the polyketide chain is unusual for fungi. Cladobotric acids A−F (1−6) exhibited notable cytotoxicity against the murine P388 leukemia cell line and were also active against Bacillus subtilis and Candida albicans.