Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder

In an earlier analysis of 73 subjects from this study, the reduced activity catechol O-methyltransferase variant was shown to be associated with obsessive-compulsive disorder in men only. We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa,...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2001-02, Vol.49 (4), p.385-388
Main Authors: ENOCH, Mary-Anne, GREENBERG, Benjamin D, MURPHY, Dennis L, GOLDMAN, David
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Anxiety disorders. Neuroses
Biological and medical sciences
Female
Genotype
Humans
Male
Medical sciences
Obsessive-Compulsive Disorder - epidemiology
Obsessive-Compulsive Disorder - metabolism
Obsessive-compulsive disorders
Polymorphism, Genetic - genetics
Promoter Regions, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin - genetics
Serotonin - metabolism
Sex Distribution
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Summary:In an earlier analysis of 73 subjects from this study, the reduced activity catechol O-methyltransferase variant was shown to be associated with obsessive-compulsive disorder in men only. We hypothesized that the 5-HT2A promoter polymorphism, -1438G>A, previously associated with anorexia nervosa, would be more abundant in women with obsessive-compulsive disorder. One hundred and one Caucasian obsessive-compulsive disorder patients (48 women, 53 men) and 138 control subjects (77 women, 61 men), were genotyped. DSM-III-R psychiatric diagnoses were assigned based on the SCID-I. As hypothesized, the -1438A allele frequency was higher in obsessive-compulsive disorder women (.57) than female control subjects (.42) (p =.015). The genotype frequencies were also significantly different (p =.020). Allele frequencies did not differ between male obsessive-compulsive disorder patients (.44) and male control subjects (.41). CCONSLUSIONS: We have found that a 5-HT2A promoter polymorphism is associated with obsessive-compulsive disorder in women but not in men, strengthening the argument that there may be fundamental gender differences in the genetic susceptibility to obsessive-compulsive disorder.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(00)01040-4