Regulation of skeletal muscle gene expression by p38 MAP kinases

The formation of skeletal muscle is a multistep process orchestrated by the basic helix–loop–helix myogenic regulatory factors (MRFs). A wide array of proteins can interact with the MRFs, resulting in either induction or repression of their myogenic potential and subsequent MRF-mediated muscle-speci...

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Bibliographic Details
Published in:Trends in cell biology 2006, Vol.16 (1), p.36-44
Main Authors: Lluís, Frederic, Perdiguero, Eusebio, Nebreda, Angel R., Muñoz-Cánoves, Pura
Format: Article
Language:English
Subjects:
Animals
Chromatin Assembly and Disassembly
Gene Expression Regulation
Humans
Muscle Development
Muscle, Skeletal - physiology
Myogenic Regulatory Factors - physiology
p38 Mitogen-Activated Protein Kinases - physiology
Transcription, Genetic
Transcriptional Activation
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Summary:The formation of skeletal muscle is a multistep process orchestrated by the basic helix–loop–helix myogenic regulatory factors (MRFs). A wide array of proteins can interact with the MRFs, resulting in either induction or repression of their myogenic potential and subsequent MRF-mediated muscle-specific transcription. Findings published over the past few years have unambiguously established a key role for the p38 MAP kinase pathway in the control of muscle gene expression at different stages of the myogenic process. Here, we discuss the mechanisms by which p38 MAP kinase controls skeletal muscle differentiation by regulating the sequential activation of MRFs and their transcriptional coactivators, including chromatin remodeling enzymes.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2005.11.002