Synthetic Applications of β-Fluoroalkylated α,β-Unsaturated Carbonyl Compounds

• Published in: Chemistry : a European journal 2006-01, Vol.12 (4), p.974-979
• Main Author: Billard, Thierry
• Format: Article
• Language: English
• Subjects: carbonyl compounds; cycloaddition; fluorine; Michael addition
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.200500466

β‐Fluoroalkylated α,β‐unsaturated carbonyl compounds constitute efficient building blocks for the synthesis of complex fluorinated compounds. As the fluorinated moiety generally increases their reactivity, it also brings important modifications which can change the chemical behavior and selectivity. Their use has been already largely demonstrated. Nevertheless, the synthetic potential has not yet been fully explored and, consequently should play an important role in the design of new sophisticated fluorinated molecules. Nevertheless, it shall be important to develop new synthetic methods to enlarge their availability and their diversity. Efficient fluorinated building blocks are required for the synthesis of complex fluorinated compounds. β‐Fluoroalkylated α,β‐unsaturated carbonyl compounds constitute efficient units for this purpose. A large diversity of reactions can be envisaged with such molecules.