Have we cut ourselves too short in mapping CTL epitopes?

MHC class I molecules generally present peptides of eight to ten amino acids; however, peptides of 11–14 residues can also elicit dominant cytotoxic T lymphocyte responses, sometimes at the expense of overlapping shorter peptides. Although long-bulged epitopes are considered to represent a barrier f...

Full description

Saved in:
Bibliographic Details
Published in:Trends in Immunology 2006, Vol.27 (1), p.11-16
Main Authors: Burrows, Scott R., Rossjohn, Jamie, McCluskey, James
Format: Article
Language:English
Subjects:
Algorithms
Animals
Cytotoxicity
Epitopes, T-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - immunology
Histocompatibility Antigens - immunology
Humans
Ligands
Lymphocytes
Peptides
Receptors, Antigen, T-Cell - chemistry
Receptors, Antigen, T-Cell - immunology
T cell receptors
T-Lymphocytes, Cytotoxic - chemistry
T-Lymphocytes, Cytotoxic - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583
cites cdi_FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583
container_end_page 16
container_issue 1
container_start_page 11
container_title Trends in Immunology
container_volume 27
creator Burrows, Scott R.
Rossjohn, Jamie
McCluskey, James
description MHC class I molecules generally present peptides of eight to ten amino acids; however, peptides of 11–14 residues can also elicit dominant cytotoxic T lymphocyte responses, sometimes at the expense of overlapping shorter peptides. Although long-bulged epitopes are considered to represent a barrier for T cell receptor recognition, recent structural data reveal how these super-bulged peptides are engaged while simultaneously maintaining MHC restriction. We propose that algorithms widely used to predict class I-binding peptides should now be broadened to include peptides of over ten residues in length.
doi_str_mv 10.1016/j.it.2005.11.001
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70687722</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1471490605002826</els_id><sourcerecordid>3245286071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583</originalsourceid><addsrcrecordid>eNqFkEtLAzEUhYMotj72riQguJsxdx7JjBuRolYouKnrkMnc0ZR2MiaZiv_eqS0Kgri6d_GdA-cj5AxYDAz41SI2IU4Yy2OAmDHYI2PIBERZWcD-98_4iBx5vxiAXAhxSEbAk1JwDmNSTNUa6TtS3Qdqe-dxuUZPg7XUv1oXqGnpSnWdaV_oZD6j2JlgO_Q3J-SgUUuPp7t7TJ7v7-aTaTR7enic3M4inTERImAJr0WOUHNe1Zg3VVVnmCLXiSqqUpUNamQVKpVkVVOmvKhYmiVNClznPC_SY3K57e2cfevRB7kyXuNyqVq0vZeC8UKIJPkXBMGKVKQb8OIXuBiGt8MICTnjZZrxrzq2pbSz3jtsZOfMSrkPCUxu5MuFNEFu5EsAObgdIue74r5aYf0T2NkegOstgIOwtUEnvTbYaqyNQx1kbc3f7Z_9BpIs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1506934622</pqid></control><display><type>article</type><title>Have we cut ourselves too short in mapping CTL epitopes?</title><source>PubMed (Medline)</source><source>Wiley</source><source>ScienceDirect Journals</source><creator>Burrows, Scott R. ; Rossjohn, Jamie ; McCluskey, James</creator><creatorcontrib>Burrows, Scott R. ; Rossjohn, Jamie ; McCluskey, James</creatorcontrib><description>MHC class I molecules generally present peptides of eight to ten amino acids; however, peptides of 11–14 residues can also elicit dominant cytotoxic T lymphocyte responses, sometimes at the expense of overlapping shorter peptides. Although long-bulged epitopes are considered to represent a barrier for T cell receptor recognition, recent structural data reveal how these super-bulged peptides are engaged while simultaneously maintaining MHC restriction. We propose that algorithms widely used to predict class I-binding peptides should now be broadened to include peptides of over ten residues in length.</description><identifier>ISSN: 1471-4906</identifier><identifier>EISSN: 1471-4981</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1016/j.it.2005.11.001</identifier><identifier>PMID: 16297661</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Algorithms ; Animals ; Cytotoxicity ; Epitopes, T-Lymphocyte - chemistry ; Epitopes, T-Lymphocyte - immunology ; Histocompatibility Antigens - immunology ; Humans ; Ligands ; Lymphocytes ; Peptides ; Receptors, Antigen, T-Cell - chemistry ; Receptors, Antigen, T-Cell - immunology ; T cell receptors ; T-Lymphocytes, Cytotoxic - chemistry ; T-Lymphocytes, Cytotoxic - immunology</subject><ispartof>Trends in Immunology, 2006, Vol.27 (1), p.11-16</ispartof><rights>2005 Elsevier Ltd</rights><rights>Copyright Elsevier Limited Jan 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583</citedby><cites>FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16297661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burrows, Scott R.</creatorcontrib><creatorcontrib>Rossjohn, Jamie</creatorcontrib><creatorcontrib>McCluskey, James</creatorcontrib><title>Have we cut ourselves too short in mapping CTL epitopes?</title><title>Trends in Immunology</title><addtitle>Trends Immunol</addtitle><description>MHC class I molecules generally present peptides of eight to ten amino acids; however, peptides of 11–14 residues can also elicit dominant cytotoxic T lymphocyte responses, sometimes at the expense of overlapping shorter peptides. Although long-bulged epitopes are considered to represent a barrier for T cell receptor recognition, recent structural data reveal how these super-bulged peptides are engaged while simultaneously maintaining MHC restriction. We propose that algorithms widely used to predict class I-binding peptides should now be broadened to include peptides of over ten residues in length.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Cytotoxicity</subject><subject>Epitopes, T-Lymphocyte - chemistry</subject><subject>Epitopes, T-Lymphocyte - immunology</subject><subject>Histocompatibility Antigens - immunology</subject><subject>Humans</subject><subject>Ligands</subject><subject>Lymphocytes</subject><subject>Peptides</subject><subject>Receptors, Antigen, T-Cell - chemistry</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>T cell receptors</subject><subject>T-Lymphocytes, Cytotoxic - chemistry</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><issn>1471-4906</issn><issn>1471-4981</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLAzEUhYMotj72riQguJsxdx7JjBuRolYouKnrkMnc0ZR2MiaZiv_eqS0Kgri6d_GdA-cj5AxYDAz41SI2IU4Yy2OAmDHYI2PIBERZWcD-98_4iBx5vxiAXAhxSEbAk1JwDmNSTNUa6TtS3Qdqe-dxuUZPg7XUv1oXqGnpSnWdaV_oZD6j2JlgO_Q3J-SgUUuPp7t7TJ7v7-aTaTR7enic3M4inTERImAJr0WOUHNe1Zg3VVVnmCLXiSqqUpUNamQVKpVkVVOmvKhYmiVNClznPC_SY3K57e2cfevRB7kyXuNyqVq0vZeC8UKIJPkXBMGKVKQb8OIXuBiGt8MICTnjZZrxrzq2pbSz3jtsZOfMSrkPCUxu5MuFNEFu5EsAObgdIue74r5aYf0T2NkegOstgIOwtUEnvTbYaqyNQx1kbc3f7Z_9BpIs</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Burrows, Scott R.</creator><creator>Rossjohn, Jamie</creator><creator>McCluskey, James</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>Have we cut ourselves too short in mapping CTL epitopes?</title><author>Burrows, Scott R. ; Rossjohn, Jamie ; McCluskey, James</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Algorithms</topic><topic>Animals</topic><topic>Cytotoxicity</topic><topic>Epitopes, T-Lymphocyte - chemistry</topic><topic>Epitopes, T-Lymphocyte - immunology</topic><topic>Histocompatibility Antigens - immunology</topic><topic>Humans</topic><topic>Ligands</topic><topic>Lymphocytes</topic><topic>Peptides</topic><topic>Receptors, Antigen, T-Cell - chemistry</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>T cell receptors</topic><topic>T-Lymphocytes, Cytotoxic - chemistry</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burrows, Scott R.</creatorcontrib><creatorcontrib>Rossjohn, Jamie</creatorcontrib><creatorcontrib>McCluskey, James</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burrows, Scott R.</au><au>Rossjohn, Jamie</au><au>McCluskey, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Have we cut ourselves too short in mapping CTL epitopes?</atitle><jtitle>Trends in Immunology</jtitle><addtitle>Trends Immunol</addtitle><date>2006</date><risdate>2006</risdate><volume>27</volume><issue>1</issue><spage>11</spage><epage>16</epage><pages>11-16</pages><issn>1471-4906</issn><eissn>1471-4981</eissn><eissn>1365-2567</eissn><abstract>MHC class I molecules generally present peptides of eight to ten amino acids; however, peptides of 11–14 residues can also elicit dominant cytotoxic T lymphocyte responses, sometimes at the expense of overlapping shorter peptides. Although long-bulged epitopes are considered to represent a barrier for T cell receptor recognition, recent structural data reveal how these super-bulged peptides are engaged while simultaneously maintaining MHC restriction. We propose that algorithms widely used to predict class I-binding peptides should now be broadened to include peptides of over ten residues in length.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16297661</pmid><doi>10.1016/j.it.2005.11.001</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1471-4906
ispartof Trends in Immunology, 2006, Vol.27 (1), p.11-16
issn 1471-4906
1471-4981
1365-2567
language eng
recordid cdi_proquest_miscellaneous_70687722
source PubMed (Medline); Wiley; ScienceDirect Journals
subjects Algorithms
Animals
Cytotoxicity
Epitopes, T-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - immunology
Histocompatibility Antigens - immunology
Humans
Ligands
Lymphocytes
Peptides
Receptors, Antigen, T-Cell - chemistry
Receptors, Antigen, T-Cell - immunology
T cell receptors
T-Lymphocytes, Cytotoxic - chemistry
T-Lymphocytes, Cytotoxic - immunology
title Have we cut ourselves too short in mapping CTL epitopes?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T20%3A51%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Have%20we%20cut%20ourselves%20too%20short%20in%20mapping%20CTL%20epitopes?&rft.jtitle=Trends%20in%20Immunology&rft.au=Burrows,%20Scott%20R.&rft.date=2006&rft.volume=27&rft.issue=1&rft.spage=11&rft.epage=16&rft.pages=11-16&rft.issn=1471-4906&rft.eissn=1471-4981&rft_id=info:doi/10.1016/j.it.2005.11.001&rft_dat=%3Cproquest_cross%3E3245286071%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c407t-1026d75e1d66bde5fbbd4e3e6c2a8b9a9fece0beaa24bf9368b0342f316c56583%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1506934622&rft_id=info:pmid/16297661&rfr_iscdi=true