Nonleaching Antimicrobial Films Prepared from Surface-Modified Microfibrillated Cellulose

We have prepared potentially permanent antimicrobial films based on surface-modified microfibrillated cellulose (MFC). MFC, obtained by disintegration of bleached softwood sulfite pulp in a homogenizer, was grafted with the quaternary ammonium compound octadecyldimethyl(3-trimethoxysilylpropyl)ammon...

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Bibliographic Details
Published in:Biomacromolecules 2007-07, Vol.8 (7), p.2149-2155
Main Authors: Andresen, Martin, Stenstad, Per, Møretrø, Trond, Langsrud, Solveig, Syverud, Kristin, Johansson, Leena-Sisko, Stenius, Per
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Applied sciences
Cellulose - chemistry
Cellulose and derivatives
Escherichia coli
Escherichia coli - drug effects
Exact sciences and technology
Microbial Sensitivity Tests
Microscopy, Electron, Scanning
Natural polymers
Physicochemistry of polymers
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Spectrophotometry, Infrared
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus
Staphylococcus aureus - drug effects
Surface Properties
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Summary:We have prepared potentially permanent antimicrobial films based on surface-modified microfibrillated cellulose (MFC). MFC, obtained by disintegration of bleached softwood sulfite pulp in a homogenizer, was grafted with the quaternary ammonium compound octadecyldimethyl(3-trimethoxysilylpropyl)ammonium chloride (ODDMAC) by a simple adsorption-curing process. Films prepared from the ODDMAC-modified MFC were characterized by Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) and tested for antibacterial activity against the Gram-positive bacterium Staphylococcus aureus and the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa. The films showed substantial antibacterial capacity even at very low concentrations of antimicrobial agent immobilized on the surface. A zone of inhibition test demonstrated that no ODDMAC diffused into the surroundings, verifying that the films were indeed of the nonleaching type.
ISSN:1525-7797
1526-4602
DOI:10.1021/bm070304e