Polyamide- and RNA-Based Activators in Living Cells: A Major Step Towards Controlling Gene Expression

Something's up! Recently, two successful approaches that lead to upregulation of gene expression in living cells have been reported. One is based on DNA‐binding polyamide–peptoid conjugates (bottom), the other on dsRNA (top). The scope and perspective of these intriguing developments are discus...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2007-07, Vol.8 (10), p.1095-1098
Main Authors: Arndt, Hans-Dieter, Schoof, Sebastian
Format: Article
Language:English
Subjects:
Dimerization
DNA - chemistry
gene expression
Gene Expression Regulation
Ligands
Models, Biological
Models, Chemical
Nucleic Acid Conformation
Nylons - chemistry
peptoids
polyamides
Protein Structure, Tertiary
RNA
RNA - chemistry
transcription factors
Transcription, Genetic
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Summary:Something's up! Recently, two successful approaches that lead to upregulation of gene expression in living cells have been reported. One is based on DNA‐binding polyamide–peptoid conjugates (bottom), the other on dsRNA (top). The scope and perspective of these intriguing developments are discussed.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200700156