Primary prophylaxis with nadolol in cirrhotic patients: Doppler patterns of splanchnic hemodynamics in good and poor responders

We aimed to characterize by echo-color-Doppler the splanchnic hemodynamics of patients good and poor responders to primary prophylaxis with nadolol. Thirty cirrhotic patients (Child-score 7.0±1.8) with medium/large esophageal varices without previous bleedings were consecutively enrolled. At inclusi...

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Bibliographic Details
Published in:Journal of hepatology 2006-02, Vol.44 (2), p.310-316
Main Authors: Berzigotti, Annalisa, Rinaldi, Maria Francesca, Magalotti, Donatella, Morelli, Maria Cristina, Zappoli, Paola, Andreone, Pietro, Rossi, Cristina, Zoli, Marco
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - therapeutic use
Antiarythmic agents
Beta-blockers
Biological and medical sciences
Blood Flow Velocity - drug effects
Blood Flow Velocity - physiology
Cardiovascular system
Disease Progression
Echo-color-Doppler
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
Hepatic Veins - diagnostic imaging
Hepatic Veins - physiopathology
Humans
HVPG
Hypertension, Portal - etiology
Hypertension, Portal - physiopathology
Hypertension, Portal - prevention & control
Investigative techniques, diagnostic techniques (general aspects)
Liver Cirrhosis - complications
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Mesenteric Arteries - diagnostic imaging
Mesenteric Arteries - physiopathology
Middle Aged
Nadolol - therapeutic use
Other diseases. Semiology
Pharmacology. Drug treatments
Portal hypertension
Primary Prevention - methods
Primary prohylaxis
Prospective Studies
Splanchnic Circulation - drug effects
Splanchnic Circulation - physiology
Treatment Outcome
Ultrasonic investigative techniques
Ultrasonography, Doppler, Duplex
Vasoconstriction - drug effects
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Summary:We aimed to characterize by echo-color-Doppler the splanchnic hemodynamics of patients good and poor responders to primary prophylaxis with nadolol. Thirty cirrhotic patients (Child-score 7.0±1.8) with medium/large esophageal varices without previous bleedings were consecutively enrolled. At inclusion and after 3 months of treatment with nadolol, they underwent a splanchnic echo-color-Doppler study and a measurement of hepatic venous pressure gradient (HVPG). Nadolol (60±36mg/day; range 20–160) induced a significant reduction of HVPG (16.6±6.1 vs. 19.4±4.6mmHg, P
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2005.10.015