Diet-induced obesity and mammary tumor development in relation to estrogen receptor status

Abstract Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body w...

Full description

Saved in:
Bibliographic Details
Published in:Cancer letters 2007-08, Vol.253 (2), p.291-300
Main Authors: Ray, Amitabha, Nkhata, Katai J, Grande, Joseph P, Cleary, Margot P
Format: Article
Language:English
Subjects:
Animals
Breast
Breast cancer
Breast Neoplasms - metabolism
Cancer
Diet
Diet-induced obesity
Dietary Fats - adverse effects
Estrogen receptor
Estrogens
Female
Hematology, Oncology and Palliative Medicine
High-Fat diet
Humans
IGF-I
Leptin
Leptin - blood
Medical research
Mice
Mice, Inbred C57BL
Neoplasm Transplantation
Obesity
Obesity - etiology
Obesity - metabolism
Proteins - analysis
Proteins - metabolism
Receptors, Estrogen - analysis
Rodents
Tumor Cells, Cultured
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Leptin enhances proliferation of estrogen receptor (ER)-positive breast cancer cells in vitro. Here, we compared mammary tumor (MT) formation from ER-positive (MCF-7) and ER-negative (MDA-MB-231) breast cancer cells in athymic mice fed a High-Fat diet to elevate serum leptin. Neither body weight, diet or serum leptin levels impacted MT latency, burden or tumor grade. However, protein expression in mammary fat pads exhibited elevated PCNA and Cyclin D1 while in MTs, Ob-Rb, IGF-IR, Bcl-2, and Bax were lower in Low-Fat versus High-Fat mice. In conclusion, diet rather than serum leptin impacted breast cancer cell tumor metabolism.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2007.02.005