Splenectomy in the context of primary cytoreductive operations for advanced epithelial ovarian cancer

To determine if the need to perform splenectomy due to metastatic disease in the context of complete primary cytoreduction for ovarian cancer diminishes the prognosis for survival. Between 1990 and 2004, 356 stage IIIC epithelial ovarian cancer patients underwent resection of all visible disease bef...

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Bibliographic Details
Published in:Gynecologic oncology 2006-02, Vol.100 (2), p.344-348
Main Authors: Eisenkop, Scott M., Spirtos, Nick M., Lin, Wei-Chien Michael
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Cohort Studies
Cytoreduction
Epithelial Cells - pathology
Female
Humans
Middle Aged
Neoplasm Staging
Ovarian cancer
Ovarian Neoplasms - pathology
Ovarian Neoplasms - surgery
Splenectomy
Splenic Neoplasms - secondary
Splenic Neoplasms - surgery
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Summary:To determine if the need to perform splenectomy due to metastatic disease in the context of complete primary cytoreduction for ovarian cancer diminishes the prognosis for survival. Between 1990 and 2004, 356 stage IIIC epithelial ovarian cancer patients underwent resection of all visible disease before systemic platinum-based combination chemotherapy. Forty-nine (13.8%) required a splenectomy due to metastatic disease. Survival was analyzed (log rank) on the basis of whether splenectomy was necessary. The frequency of performing other procedures, operative time, blood loss, transfusion rate, and hospitalization, was compared (Chi-square test; discrete and binomial data, t test; continuous data) on the basis of whether a splenectomy was required. Survival was not influenced (log rank) by the requirement of splenectomy (required; median 56.4 months, estimated 5-year survival of 48% vs. not required; median 76.8 months, estimated 5-year survival of 58% P = 0.4). The splenectomy subgroup more commonly required en-bloc resection of reproductive organs with rectosigmoid (89.8% vs. 55.7%, P 
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2005.08.036