Leptin infusion during the early luteal phase in ewes does not affect progesterone production

Infusion of leptin during the ovine follicular phase has been shown to increase progesterone secretion during the subsequent luteal phase. In this study, we have assessed the effects of infusing leptin during the early luteal phase. Infusion of leptin (2.5 μg/h) into the ovarian artery of ewes with...

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Bibliographic Details
Published in:Domestic animal endocrinology 2007-08, Vol.33 (2), p.240-244
Main Authors: Nicklin, L.T., Robinson, R.S., Campbell, B.K., Hunter, M.G., Mann, G.E.
Format: Article
Language:English
Subjects:
Animals
Corpus luteum
Corpus Luteum - metabolism
estradiol
Estradiol - metabolism
estrous cycle
Estrous Cycle - physiology
ewes
Female
hormone secretion
leptin
Leptin - physiology
luteal cells
luteinizing hormone
Luteinizing Hormone - metabolism
Ovulation - physiology
progesterone
Progesterone - metabolism
Sheep
Sheep - blood
steroidogenesis
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Summary:Infusion of leptin during the ovine follicular phase has been shown to increase progesterone secretion during the subsequent luteal phase. In this study, we have assessed the effects of infusing leptin during the early luteal phase. Infusion of leptin (2.5 μg/h) into the ovarian artery of ewes with ovarian autotransplants ( n = 5) on day 3 of the luteal phase for 12 h did not affect progesterone estradiol or LH concentrations compared to control ewes ( n = 5). These results suggest no direct effect of leptin on ovarian function at this stage of the estrous cycle.
ISSN:0739-7240
1879-0054
DOI:10.1016/j.domaniend.2006.05.003