Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules

A novel and efficient method for preparing 188Re(I) tricarbonyl precursor [188Re(OH2)3(CO)3]+ has been developed by reacting [188Re]perrhenate with Schibli's kit in the presence of borohydride exchange resin (BER) as a reducing agent and an anion scavanger. The precursor was produced in more th...

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Published in:Bioconjugate chemistry 2006-01, Vol.17 (1), p.223-225
Main Authors: Park, Sang Hyun, Seifert, Sepp, Pietzsch, Hans-Jurgen
Format: Article
Language:English
Subjects:
Biochemistry
Borohydrides - chemistry
Ion Exchange Resins
Ions
Molecular biology
Organometallic Compounds - chemistry
Oxidation-Reduction
Radioisotopes
Radiopharmaceuticals - chemical synthesis
Rhenium
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cited_by cdi_FETCH-LOGICAL-a444t-cbdabd76106f5091fba059b17c266a3c4a648d2e198c4ebe79d1b5ea7c596ab63
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container_title Bioconjugate chemistry
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creator Park, Sang Hyun
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Pietzsch, Hans-Jurgen
description A novel and efficient method for preparing 188Re(I) tricarbonyl precursor [188Re(OH2)3(CO)3]+ has been developed by reacting [188Re]perrhenate with Schibli's kit in the presence of borohydride exchange resin (BER) as a reducing agent and an anion scavanger. The precursor was produced in more than 97% yield by reacting a solution of tetrahydroborate exchange resin (BER, 3 mg), borane−ammonia (BH3·NH3, 3 mg), and potassium boranocarbonate (K2[H3BCO2], 3 mg) in 0.9% saline with a solution of sodium perrhenate (Na188ReO4) with up to 50 MBq and concentrated phosphoric acid (85%, 7 μL) at 60 °C for 15 min. HPLC and TLC revealed 0% unreacted [188Re]perrhenate ion and
doi_str_mv 10.1021/bc050192t
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The precursor was produced in more than 97% yield by reacting a solution of tetrahydroborate exchange resin (BER, 3 mg), borane−ammonia (BH3·NH3, 3 mg), and potassium boranocarbonate (K2[H3BCO2], 3 mg) in 0.9% saline with a solution of sodium perrhenate (Na188ReO4) with up to 50 MBq and concentrated phosphoric acid (85%, 7 μL) at 60 °C for 15 min. HPLC and TLC revealed 0% unreacted [188Re]perrhenate ion and &lt;3% of colloidal 188ReO2. 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source American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list)
subjects Biochemistry
Borohydrides - chemistry
Ion Exchange Resins
Ions
Molecular biology
Organometallic Compounds - chemistry
Oxidation-Reduction
Radioisotopes
Radiopharmaceuticals - chemical synthesis
Rhenium
title Novel and Efficient Preparation of Precursor [188Re(OH2)3(CO)3]+ for the Labeling of Biomolecules
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