CARD games between virus and host get a new player

A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAV...

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Bibliographic Details
Published in:Trends in Immunology 2006, Vol.27 (1), p.1-4
Main Authors: Johnson, Cynthia L., Gale, Michael
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Caspases - metabolism
Enzyme Activation
Hepatitis C virus
Humans
Immune system
Infections
Kinases
Mitochondria - metabolism
Models, Biological
Proteins
Recruitment
Signal Transduction
Studies
Viral infections
Virus Diseases - enzymology
Virus Diseases - virology
Viruses
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Summary:A growing family of cellular proteins encoding the caspase activation and recruitment domain (CARD) has a crucial role in immunity by sensing virus infection and signaling antiviral immune defenses. Four independent studies have identified a novel CARD-containing protein, variously called IPS-1, MAVS, VISA and Cardif, which is an essential signaling adaptor of the host defense mediating CARD–CARD interactions with retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDAS), sensors of virus infection. Disruption of this novel signaling pathway by hepatitis C virus (HCV) might provide a foundation for viral persistence.
ISSN:1471-4906
1471-4981
1365-2567
DOI:10.1016/j.it.2005.11.004