Development of Nanoparticle Libraries for Biosensing

Magnetic and magnetofluorescent nanoparticles have become important materials for biological applications especially for sensing, separation, and imaging. To achieve target specificity, these nanomaterials are often covalently modified with binding proteins such as antibodies or proteins. Here we re...

Full description

Saved in:
Bibliographic Details
Published in:Bioconjugate chemistry 2006-01, Vol.17 (1), p.109-113
Main Authors: Sun, Eric Yi, Josephson, Lee, Kelly, Kim A, Weissleder, Ralph
Format: Article
Language:English
Subjects:
Amines - chemistry
Anhydrides - chemistry
Biochemistry
Biosensing Techniques
Biosensors
Carboxylic Acids - chemistry
Epoxy Compounds - chemistry
Hydroxides - chemistry
Magnetics
Magnetism
Nanoparticles
Nanostructures - chemistry
Proteins
Sulfhydryl Compounds - chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Magnetic and magnetofluorescent nanoparticles have become important materials for biological applications especially for sensing, separation, and imaging. To achieve target specificity, these nanomaterials are often covalently modified with binding proteins such as antibodies or proteins. Here we report on the creation of nanoparticle libraries that achieve specificity through multivalent modification with small molecules. We explore different synthetic routes to attach small molecules with anhydride, amine, hydroxyl carboxyl, thiol, and epoxy handles. We show that the derived nanomaterials have unique biological functions, possess different behaviors in cell screens, and can be used as substrates for biological screens.
ISSN:1043-1802
1520-4812
DOI:10.1021/bc050290e