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Development of Nanoparticle Libraries for Biosensing
Magnetic and magnetofluorescent nanoparticles have become important materials for biological applications especially for sensing, separation, and imaging. To achieve target specificity, these nanomaterials are often covalently modified with binding proteins such as antibodies or proteins. Here we re...
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| Published in: | Bioconjugate chemistry 2006-01, Vol.17 (1), p.109-113 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a409t-5aeb6b7719082037cd6fbc85cb9858e8570280169492e69e01b16ff8dd7082033 |
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| cites | cdi_FETCH-LOGICAL-a409t-5aeb6b7719082037cd6fbc85cb9858e8570280169492e69e01b16ff8dd7082033 |
| container_end_page | 113 |
| container_issue | 1 |
| container_start_page | 109 |
| container_title | Bioconjugate chemistry |
| container_volume | 17 |
| creator | Sun, Eric Yi Josephson, Lee Kelly, Kim A Weissleder, Ralph |
| description | Magnetic and magnetofluorescent nanoparticles have become important materials for biological applications especially for sensing, separation, and imaging. To achieve target specificity, these nanomaterials are often covalently modified with binding proteins such as antibodies or proteins. Here we report on the creation of nanoparticle libraries that achieve specificity through multivalent modification with small molecules. We explore different synthetic routes to attach small molecules with anhydride, amine, hydroxyl carboxyl, thiol, and epoxy handles. We show that the derived nanomaterials have unique biological functions, possess different behaviors in cell screens, and can be used as substrates for biological screens. |
| doi_str_mv | 10.1021/bc050290e |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 1043-1802 |
| ispartof | Bioconjugate chemistry, 2006-01, Vol.17 (1), p.109-113 |
| issn | 1043-1802 1520-4812 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70693159 |
| source | American Chemical Society:Jisc Collections:American Chemical Society Read & Publish Agreement 2022-2024 (Reading list) |
| subjects | Amines - chemistry Anhydrides - chemistry Biochemistry Biosensing Techniques Biosensors Carboxylic Acids - chemistry Epoxy Compounds - chemistry Hydroxides - chemistry Magnetics Magnetism Nanoparticles Nanostructures - chemistry Proteins Sulfhydryl Compounds - chemistry |
| title | Development of Nanoparticle Libraries for Biosensing |
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