Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies

Abstract Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B....

Full description

Saved in:
Bibliographic Details
Published in:FEMS immunology and medical microbiology 2006-02, Vol.46 (1), p.39-47
Main Authors: Rodríguez, María Eugenia, Hellwig, Sandra M.M., Pérez Vidakovics, María L.A., Berbers, Guy A.M., van de Winkel, Jan G. J.
Format: Article
Language:English
Subjects:
Agglutination
Antibodies
Antibodies, Bacterial - blood
Antibodies, Bacterial - isolation & purification
Antibodies, Bacterial - pharmacology
antibody
Attachment
Bacteriology
Biological and medical sciences
Bordetella pertussis
Bordetella pertussis - drug effects
Bordetella pertussis - immunology
Colonization
Epithelial cells
fimbriae
Fimbriae, Bacterial - drug effects
Fimbriae, Bacterial - immunology
Fundamental and applied biological sciences. Psychology
host protection
Humans
Immunoglobulin A
Immunoglobulin A - pharmacology
Immunoglobulin G
Immunoglobulin G - pharmacology
Immunoglobulins
Microbiology
Miscellaneous
Pertussis
Pili
Respiratory Mucosa - drug effects
Respiratory Mucosa - microbiology
Vaccination
Whooping cough
Whooping Cough - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon.
ISSN:0928-8244
1574-695X
2049-632X
DOI:10.1111/j.1574-695X.2005.00001.x