Hypophosphatemic rickets: results of a long-term follow-up

This study reports the benefits and side effects of conventional treatment, phosphate and calcitriol supplementation in patients with heritable hypophosphatemic rickets and a long-term follow-up, median of 60.9 months. The group is composed of 17 patients (ten girls). Sixteen patients presented with...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2006-02, Vol.21 (2), p.230-234
Main Authors: Vaisbich, Maria Helena, Koch, Vera H
Format: Article
Language:English
Subjects:
Acidosis
Bone surgery
Calcitriol
Child, Preschool
Creatinine
Drug therapy
Female
Follow-Up Studies
Health aspects
Humans
Hypophosphatemia
Hypophosphatemia, Familial - therapy
Infant
Male
Metabolism
Nephrology
Patients
Pediatrics
Phosphatase
Phosphates
Potassium
Rickets
Standard scores
Time Factors
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Summary:This study reports the benefits and side effects of conventional treatment, phosphate and calcitriol supplementation in patients with heritable hypophosphatemic rickets and a long-term follow-up, median of 60.9 months. The group is composed of 17 patients (ten girls). Sixteen patients presented with bone pain and/or deformities, and in one patient the diagnosis was radiological. All the patients had increased alkaline phosphatase, hypophosphatemia, decreased fractional phosphate tubular reabsorption (TRP) and maximum tubular phosphate reabsorption/glomerular filtration rate ratio (TPO4/GFR). Ten of 17 patients had metabolic acidosis, which was corrected only with the conventional treatment. Potassium citrate was prescribed to the patients who developed hypercalciuria. Excluding one patient with pulmonary dysfunction, the remaining 16 patients were divided into two groups according to the age at treatment onset (T0): group I (GI) > or =4 years (n =9) and GII
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-005-2077-4