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Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats
Dehydroepiandrosterone (DHEA), the predominant steroid hormone produced by adrenal glands has significant effects on the immune system. DHEA enhances immune responses against a wide range of viral, bacterial, and parasitic pathogens. In the present study, we investigated the effects of DHEA treatmen...
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Published in: | Acta tropica 2007-06, Vol.102 (3), p.143-150 |
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container_title | Acta tropica |
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creator | Santos, Carla Domingues Toldo, Míriam Paula Alonso Levy, Antonio Marcos Apparecida Kawasse, Laura Midori Zucoloto, Sérgio do Prado, José Clóvis |
description | Dehydroepiandrosterone (DHEA), the predominant steroid hormone produced by adrenal glands has significant effects on the immune system. DHEA enhances immune responses against a wide range of viral, bacterial, and parasitic pathogens. In the present study, we investigated the effects of DHEA treatment during the acute phase of experimental
Trypanosoma cruzi infection. Male and female Wistar rats were infected with the Y strain of
T. cruzi and treated subcutaneously with 40
mg/kg body weight/day of DHEA. Myocardial parasitism and inflammation were always present in the heart during the acute phase, in male and female infected animals, regardless of DHEA treatment, but the numbers of amastigote nests in cardiomyocytes were significantly lower in DHEA-treated rats. At the end of the acute phase, the nests became rare or virtually absent in all experimental infections. Histological analysis of the adrenal glands showed that treated males displayed an absence of parasites. DHEA treatment also resulted in reduced parasitisim of heart and adrenal glands, as indicated by fewer and smaller amastigote burdens, and less inflammatory infiltrate and tissue disorganization. DHEA treatment also resulted in thymic atrophy as measured both by reduced weight and by a reduction in the number of cultured activated thymocytes. In vitro analysis showed the number of activated macrophages was higher in treated animals. Antibody levels were monitored by complement-mediated lysis. Higher titers were observed in females when compared to males; but DHEA treatment enhanced the percentage of lysis for both sexes. These findings suggest that DHEA can play a role in the control of parasite multiplication. |
doi_str_mv | 10.1016/j.actatropica.2007.04.010 |
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Trypanosoma cruzi infection. Male and female Wistar rats were infected with the Y strain of
T. cruzi and treated subcutaneously with 40
mg/kg body weight/day of DHEA. Myocardial parasitism and inflammation were always present in the heart during the acute phase, in male and female infected animals, regardless of DHEA treatment, but the numbers of amastigote nests in cardiomyocytes were significantly lower in DHEA-treated rats. At the end of the acute phase, the nests became rare or virtually absent in all experimental infections. Histological analysis of the adrenal glands showed that treated males displayed an absence of parasites. DHEA treatment also resulted in reduced parasitisim of heart and adrenal glands, as indicated by fewer and smaller amastigote burdens, and less inflammatory infiltrate and tissue disorganization. DHEA treatment also resulted in thymic atrophy as measured both by reduced weight and by a reduction in the number of cultured activated thymocytes. In vitro analysis showed the number of activated macrophages was higher in treated animals. Antibody levels were monitored by complement-mediated lysis. Higher titers were observed in females when compared to males; but DHEA treatment enhanced the percentage of lysis for both sexes. These findings suggest that DHEA can play a role in the control of parasite multiplication.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2007.04.010</identifier><identifier>PMID: 17560841</identifier><identifier>CODEN: ACTRAQ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Chagas Disease - drug therapy ; Chagas Disease - parasitology ; Dehydroepiandrosterone ; Dehydroepiandrosterone - pharmacology ; Female ; General aspects ; Heart - parasitology ; Infectious diseases ; Lytic antibody ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - parasitology ; Male ; Medical sciences ; Parasitic diseases ; Rats ; Rats, Wistar ; Tissue parasitism ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects</subject><ispartof>Acta tropica, 2007-06, Vol.102 (3), p.143-150</ispartof><rights>2007 Elsevier B.V.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-95e4b3c46043ffcba135eda42e8c6609980af736d4911ccc7493c4e04f5a14b3</citedby><cites>FETCH-LOGICAL-c467t-95e4b3c46043ffcba135eda42e8c6609980af736d4911ccc7493c4e04f5a14b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18913368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17560841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santos, Carla Domingues</creatorcontrib><creatorcontrib>Toldo, Míriam Paula Alonso</creatorcontrib><creatorcontrib>Levy, Antonio Marcos Apparecida</creatorcontrib><creatorcontrib>Kawasse, Laura Midori</creatorcontrib><creatorcontrib>Zucoloto, Sérgio</creatorcontrib><creatorcontrib>do Prado, José Clóvis</creatorcontrib><title>Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Dehydroepiandrosterone (DHEA), the predominant steroid hormone produced by adrenal glands has significant effects on the immune system. DHEA enhances immune responses against a wide range of viral, bacterial, and parasitic pathogens. In the present study, we investigated the effects of DHEA treatment during the acute phase of experimental
Trypanosoma cruzi infection. Male and female Wistar rats were infected with the Y strain of
T. cruzi and treated subcutaneously with 40
mg/kg body weight/day of DHEA. Myocardial parasitism and inflammation were always present in the heart during the acute phase, in male and female infected animals, regardless of DHEA treatment, but the numbers of amastigote nests in cardiomyocytes were significantly lower in DHEA-treated rats. At the end of the acute phase, the nests became rare or virtually absent in all experimental infections. Histological analysis of the adrenal glands showed that treated males displayed an absence of parasites. DHEA treatment also resulted in reduced parasitisim of heart and adrenal glands, as indicated by fewer and smaller amastigote burdens, and less inflammatory infiltrate and tissue disorganization. DHEA treatment also resulted in thymic atrophy as measured both by reduced weight and by a reduction in the number of cultured activated thymocytes. In vitro analysis showed the number of activated macrophages was higher in treated animals. Antibody levels were monitored by complement-mediated lysis. Higher titers were observed in females when compared to males; but DHEA treatment enhanced the percentage of lysis for both sexes. These findings suggest that DHEA can play a role in the control of parasite multiplication.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chagas Disease - drug therapy</subject><subject>Chagas Disease - parasitology</subject><subject>Dehydroepiandrosterone</subject><subject>Dehydroepiandrosterone - pharmacology</subject><subject>Female</subject><subject>General aspects</subject><subject>Heart - parasitology</subject><subject>Infectious diseases</subject><subject>Lytic antibody</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - parasitology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tissue parasitism</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkcFu1DAQhi0EotuWV0DhALeEceI49hFtgSJVKoc99GbNOmPh1W4SPAnS9ulxtSuVWzmNLX2_PTOfEB8kVBKk_ryr0M84p3GKHqsaoKtAVSDhlVhJ0zWlrlv1WqwAQJYd6IcLccm8y7e6a-u34kJ2rQaj5Er8vKFfxz6NNEUccuWZ0jhQgSGQn7nYpOOEw8jjAQuflsdYzJF5oWLChBxnKrZL6mngIg5FwpmvxZuAe6Z353olNt--bta35d399x_rL3elV7qbS9uS2jb5DKoJwW9RNi31qGoyXmuw1gCGrtG9slJ67ztlM02gQosyJ6_Ep9OzUxp_L8SzO0T2tN_jQOPCLk9tdWvgRbCpayu1sS-C0hqtpGwyaE-gz-viRMFNKR4wHZ0E9-TH7dw_ftyTHwfKZT85-_78ybI9UP-cPAvJwMczgOxxHxIOPvIzZ2zuQJvMrU8c5R3_iZQc-0iDpz6mLM71Y_yPdv4CeOu1gQ</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Santos, Carla Domingues</creator><creator>Toldo, Míriam Paula Alonso</creator><creator>Levy, Antonio Marcos Apparecida</creator><creator>Kawasse, Laura Midori</creator><creator>Zucoloto, Sérgio</creator><creator>do Prado, José Clóvis</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>M7N</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats</title><author>Santos, Carla Domingues ; Toldo, Míriam Paula Alonso ; Levy, Antonio Marcos Apparecida ; Kawasse, Laura Midori ; Zucoloto, Sérgio ; do Prado, José Clóvis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-95e4b3c46043ffcba135eda42e8c6609980af736d4911ccc7493c4e04f5a14b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chagas Disease - drug therapy</topic><topic>Chagas Disease - parasitology</topic><topic>Dehydroepiandrosterone</topic><topic>Dehydroepiandrosterone - pharmacology</topic><topic>Female</topic><topic>General aspects</topic><topic>Heart - parasitology</topic><topic>Infectious diseases</topic><topic>Lytic antibody</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - parasitology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tissue parasitism</topic><topic>Trypanosoma cruzi</topic><topic>Trypanosoma cruzi - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santos, Carla Domingues</creatorcontrib><creatorcontrib>Toldo, Míriam Paula Alonso</creatorcontrib><creatorcontrib>Levy, Antonio Marcos Apparecida</creatorcontrib><creatorcontrib>Kawasse, Laura Midori</creatorcontrib><creatorcontrib>Zucoloto, Sérgio</creatorcontrib><creatorcontrib>do Prado, José Clóvis</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santos, Carla Domingues</au><au>Toldo, Míriam Paula Alonso</au><au>Levy, Antonio Marcos Apparecida</au><au>Kawasse, Laura Midori</au><au>Zucoloto, Sérgio</au><au>do Prado, José Clóvis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2007-06-01</date><risdate>2007</risdate><volume>102</volume><issue>3</issue><spage>143</spage><epage>150</epage><pages>143-150</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><coden>ACTRAQ</coden><abstract>Dehydroepiandrosterone (DHEA), the predominant steroid hormone produced by adrenal glands has significant effects on the immune system. DHEA enhances immune responses against a wide range of viral, bacterial, and parasitic pathogens. In the present study, we investigated the effects of DHEA treatment during the acute phase of experimental
Trypanosoma cruzi infection. Male and female Wistar rats were infected with the Y strain of
T. cruzi and treated subcutaneously with 40
mg/kg body weight/day of DHEA. Myocardial parasitism and inflammation were always present in the heart during the acute phase, in male and female infected animals, regardless of DHEA treatment, but the numbers of amastigote nests in cardiomyocytes were significantly lower in DHEA-treated rats. At the end of the acute phase, the nests became rare or virtually absent in all experimental infections. Histological analysis of the adrenal glands showed that treated males displayed an absence of parasites. DHEA treatment also resulted in reduced parasitisim of heart and adrenal glands, as indicated by fewer and smaller amastigote burdens, and less inflammatory infiltrate and tissue disorganization. DHEA treatment also resulted in thymic atrophy as measured both by reduced weight and by a reduction in the number of cultured activated thymocytes. In vitro analysis showed the number of activated macrophages was higher in treated animals. Antibody levels were monitored by complement-mediated lysis. Higher titers were observed in females when compared to males; but DHEA treatment enhanced the percentage of lysis for both sexes. These findings suggest that DHEA can play a role in the control of parasite multiplication.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17560841</pmid><doi>10.1016/j.actatropica.2007.04.010</doi><tpages>8</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Chagas Disease - drug therapy Chagas Disease - parasitology Dehydroepiandrosterone Dehydroepiandrosterone - pharmacology Female General aspects Heart - parasitology Infectious diseases Lytic antibody Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - parasitology Male Medical sciences Parasitic diseases Rats Rats, Wistar Tissue parasitism Trypanosoma cruzi Trypanosoma cruzi - drug effects |
title | Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats |
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